5-Chloro-4-fluoroindoline CAS 1222804-82-1
| CAS No. | 1222804-82-1 |
| Molecular Formula | C8H7ClFN |
| Molecular Weight | 171.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-Chloro-4-fluoroindoline is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-Chloro-4-fluoroindoline (CAS 1222804-82-1), molecular formula C8H7ClFN and molecular weight 171.60 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C8H7ClFN, 5-Chloro-4-fluoroindoline contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 171.60 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-4-fluoroindoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7ClFN |
| Molecular Weight | 171.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 4-Chloro-6-fluoroindoline (CAS 1003005-39-7)
- 7-Chloro-4-fluoroindoline (CAS 1700248-22-1)
- 2-Chloro-5-(1-fluorocyclopropyl)pyridine (CAS 2839739-50-1)
- 4-Chloro-5-fluoroindoline (CAS 903551-32-6)
- 5-Chloro-6-fluoroindoline (CAS 935272-19-8)
- 5-Chloro-7-fluoroindoline (CAS 954264-12-1)
- 6-CHLORO-5-FLUORO-2,3-DIHYDRO-1H-INDOLE (CAS 205584-67-4)
- 7-Chloro-5-fluoroindoline (CAS 953903-54-3)
Recommended Standards
- 5-Allyl-2-chloro-3-fluoropyridine (CAS 1353529-74-4)
- 6-Chloro-5,7-dihydro-4H-purin-2-amine (CAS 851212-98-1)
- 6-Chloro-2-Picolinic Acid-Methyl Ester (CAS 6636-55-1)
- 5-Chloro-2-Nitrotoluene (CAS 5367-28-2)
- 2-(4-tert-butyl-2,6-dimethylphenyl)ethanamine (CAS 93720-89-9)
- 2-(4-Acetamido-1h-pyrazol-1-yl)acetic acid (CAS 6647-90-1)
- 3-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-3-iminopropanenitrile (CAS 339103-92-3)
- (2-Amino-4-methylphenyl)dimethylphosphine oxide (CAS 2361982-50-3)
- 1-(2-Chloro-6-fluorobenzyl)-1h-pyrazol-4-amine (CAS 957006-06-3)
- (4-ethyl-4H-1,2,4-triazol-3-yl)methanol (CAS 497854-98-5)
- 2-(Pyrimidin-4-yl)cyclopropane-1-carboxylic acid (CAS 1342359-21-0)
- 3-(3-Bromophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid (CAS 1326815-55-7)
- 1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] (CAS 180082-56-8)
- Peptide WE-14 (CAS 115136-18-0)
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