Exemestane EP Impurity H CAS 122370-91-6
| CAS No. | 122370-91-6 |
| Molecular Formula | C20H26O2 |
| Molecular Weight | 298.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Exemestane EP Impurity H (CAS 122370-91-6), a pharmacopoeial impurity reference standard (molecular formula C20H26O2, MW 298.42 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C20H26O2, Exemestane EP Impurity H contains a steroid core, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 298.42 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H26O2 |
| Molecular Weight | 298.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
Related Exemestane Standards
- Exemestane EP Impurity E (CAS 19457-55-7)
- Exemestane EP Impurity F (CAS 72648-46-5)
- Exemestane-d3 (CAS 107868-30-4 (unlabelled))
- Exemestane Impurity 17 (CAS 10104-53-7)
- Exemestane-13C,D3 (CAS CATO-C4X-164116)
- Exemestane Impurity 36 (CAS CATO-C4X-164136)
- Exemestane (CAS 107868-30-4)
- Exemestane Impurity 25 (CAS 2467590-81-2)
Recommended Standards
- Norethisterone EP Impurity G (CAS 38673-36-8)
- Betamethasone Impurity 126 (CAS 90039-84-2)
- Norethisterone EP Impurity D (CAS 68-23-5)
- Diphenhydramine impurity 18 (CAS 150556-79-9)
- Piracetam Impurity 11 (CAS 598-41-4)
- Cefotiam Impurity 44 (CAS CATO-C4X-120444)
- Tipiracil Impurity 2 (CAS CATO-C4X-10052)
- 3-((3-Methylbut-2-en-1-yl)oxy)azetidine (CAS 1339098-86-0)
- (5-Bromo-2-methyl-3-(trifluoromethyl)phenyl)methanol (CAS 1266728-52-2)
- 1,3-Benzodioxol-5-yl-1-pyrrolidinyl-methanone (CAS 64654-10-0)
- 1-(2-Aminoethyl)pyrimidine-2,4(1h,3h)-dione (CAS 34386-72-6)
- 2-((2,4,5-Trichlorophenyl)sulfonamido)benzamide (CAS 902698-59-3)
- 5-(1-aminoethyl)-2,3-dihydro-1H-1,2,4-triazol-3-one hydrochloride (CAS 879635-12-8)
- Tirzepatide Impurity 51 (CAS CATO-C4X-324051)
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