Exemestane EP Impurity F CAS 72648-46-5
| CAS No. | 72648-46-5 |
| Molecular Formula | C19H22O3 |
| Molecular Weight | 298.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, a hydroxyl group, an ether linkage, Exemestane EP Impurity F is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 298.38 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Exemestane EP Impurity F (CAS 72648-46-5, C19H22O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22O3 |
| Molecular Weight | 298.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
Related Exemestane Standards
- Exemestane EP Impurity E (CAS 19457-55-7)
- Exemestane EP Impurity H (CAS 122370-91-6)
- Exemestane-d3 (CAS 107868-30-4 (unlabelled))
- Exemestane (CAS 107868-30-4)
- Exemestane Impurity 25 (CAS 2467590-81-2)
- Exemestane Impurity 17 (CAS 10104-53-7)
- Exemestane-13C,D3 (CAS CATO-C4X-164116)
- Exemestane Impurity 36 (CAS CATO-C4X-164136)
Recommended Standards
- Atomoxetine Impurity 23 (CAS CATO-C4X-155023)
- Prednisone EP Impurity K (CAS 7738-93-4)
- Ketoprofen Impurity 81 (CAS CATO-C4X-147181)
- Dopamine Impurity 61 (CAS CATO-C4X-190861)
- Trifluridine Impurity 11 (CAS CATO-C4X-205611)
- Pimavanserin impurity 64 (CAS 37806-39-6（free base）)
- Fluocinolone Acetonide Impurity N1 (CAS 6598-95-4)
- 2-(4-(P-tolyl)tetrahydro-2h-pyran-4-yl)acetic acid (CAS 33451-58-0)
- Ald-Ph-PEG2-Boc (CAS 2100306-65-6)
- (S)-Methyl 3-amino-3-(3-nitrophenyl)hexanoate hydrochloride (CAS 1363408-49-4)
- CAS 50909-46-1 (CAS 50909-46-1)
- Capivasertib Impurity 8 (CAS CATO-C4X-33128)
- cis-2-(butoxycarbonyl)cyclopropane-1-carboxylic acid (CAS 2055841-08-0)
- Semaglutide impurity 195 (CAS CATO-C4X-2226195)
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