5-(3,5-Difluorophenyl)pyridin-3-amine CAS 1225914-83-9
| CAS No. | 1225914-83-9 |
| Molecular Formula | C11H8F2N2 |
| Molecular Weight | 206.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-(3,5-Difluorophenyl)pyridin-3-amine (CAS 1225914-83-9) is a high-purity analytical reference standard with the molecular formula C11H8F2N2 and a molecular weight of 206.19 g/mol.
The molecular framework of 5-(3,5-Difluorophenyl)pyridin-3-amine (C11H8F2N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H8F2N2 |
| Molecular Weight | 206.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluorophenyl Standards
- 6-(2,5-Difluorophenyl)pyridin-2-amine (CAS 1178652-18-0)
- 4-(2,5-Difluorophenyl)phenol (CAS 1181291-45-1)
- 6-(3,4-Difluorophenyl)pyridin-3-amine (CAS 1225914-71-5)
- 2-(2,4-Difluorophenyl)phenol (CAS 1225946-59-7)
- 5-(3,4-Difluorophenyl)pyridin-3-amine (CAS 1226415-43-5)
- 3-(2,4-Difluorophenyl)pyridin-4-amine (CAS 1258613-25-0)
- 3-(2,6-Difluorophenyl)phenol (CAS 1261910-30-8)
- 3-(2,3-Difluorophenyl)phenol (CAS 1261957-50-9)
Recommended Standards
- 4,5-difluoro-1H-1,3-benzodiazole-2-carboxylic acid (CAS 1225283-27-1)
- 4-(3-Fluorophenyl)-2-fluorophenol (CAS 1214390-52-9)
- 4-Ethoxybenzofuran-6-carboxylic acid (CAS 1239847-63-2)
- 2,6-Difluoro-4-(pyridin-4-yl)aniline (CAS 1214387-96-8)
- 2-(2,4-Dimethylphenoxymethyl)oxirane (CAS 20217-04-3)
- Prednisone-d4 (Major) (CAS CATO-CCAD303314)
- 2-(3-Chloro-phenoxy)-thiazole-4-carboxylic acid ethyl ester (CAS 162276-40-6)
- Methyl 4-(3,5-difluorophenyl)-3-fluorobenzoate (CAS 1820711-01-0)
- phenyl(3-phenylaziridin-2-yl)methanone (CAS 51659-21-3)
- 2-[1-[(3-chlorophenyl)methyl]-3-indolyl]acetic acid 2-[1-[(3-chlorophenyl)methyl]indol-3-yl]ethanoic acid 339016-33-0 A821993 (CAS 339016-33-0)
- 5-Benzyl-3a-methyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione (CAS 2791272-34-7)
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