2-(6-Bromo-5-fluoro-1H-indol-3-yl)acetic acid CAS 1227563-84-9
| CAS No. | 1227563-84-9 |
| Molecular Formula | C10H7BrFNO2 |
| Molecular Weight | 272.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(6-Bromo-5-fluoro-1H-indol-3-yl)acetic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(6-Bromo-5-fluoro-1H-indol-3-yl)acetic acid (CAS 1227563-84-9) is a high-purity analytical reference standard with the molecular formula C10H7BrFNO2 and a molecular weight of 272.07 g/mol.
2-(6-Bromo-5-fluoro-1H-indol-3-yl)acetic acid (C10H7BrFNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(6-Bromo-5-fluoro-1H-indol-3-yl)acetic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7BrFNO2 |
| Molecular Weight | 272.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 5-Bromo-7-fluoroindole-3-acetic Acid (CAS 1019111-81-9)
- 2-(4-Bromo-2-fluorophenyl)-1,2-dihydro-5-methyl-3H-1,2,4-triazol-3-one (CAS 111992-09-7)
- 4-Bromo-2,3-difluorobenzenesulfonamide (CAS 1133123-01-9)
- 2-(7-Bromo-4-fluoro-1H-indol-3-yl)acetic acid (CAS 1227496-22-1)
- 2-(6-Bromo-4-fluoro-1H-indol-3-yl)acetic acid (CAS 1227502-64-8)
- 2-(5-Bromo-6-fluoro-1H-indol-3-yl)acetic acid (CAS 1227576-93-3)
- 4-Bromo-7-fluoroindole-3-acetic Acid (CAS 1227598-12-0)
- 2-(7-Bromo-5-fluoro-1H-indol-3-yl)acetic acid (CAS 1227598-38-0)
Recommended Standards
- 5-Fluoro-3-(perfluoroethyl)-4-(trifluoromethyl)-1H-pyrazole (CAS 1174395-13-1)
- 2-(5-(Difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1142228-23-6)
- (1-(4-Bromo-2-fluorophenyl)-1H-1,2,3-triazol-4-yl)methanol (CAS 1247801-56-4)
- (1-(2-Bromo-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methanol (CAS 1248968-81-1)
- 1-Bromo-3,5-dichloro-4-(methoxymethyl)benzene (CAS 2121512-85-2)
- 2-Amino-3-(tert-butyl)benzaldehyde (CAS 1289209-61-5)
- AZD-PEG2-acid (CAS 1807518-70-2)
- Methyl 6-methyl-2,3,4,5-tetrahydropyridazine-3-carboxylate (CAS 344596-94-7)
- 5-Bromo-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid (CAS 1956307-68-8)
- 3-(4-(4,6-Dimethylpyrimidin-2-yl)piperazin-1-yl)propanoic acid (CAS 883537-94-8)
- 1,2,3,4-Tetrahydro-6-methoxy-3-methylquinoline (CAS 184041-83-6)
- 4-Chloro-6-methyl-8-nitroquinoline (CAS 190140-02-4)
- Ethyl (ethylglycyl)carbamate hydrochloride (CAS 1172334-11-0)
- Atrial Natriuretic Polypeptide (4-28), human (CAS 95896-08-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com