2-(7-Bromo-5-fluoro-1H-indol-3-yl)acetic acid CAS 1227598-38-0
| CAS No. | 1227598-38-0 |
| Molecular Formula | C10H7BrFNO2 |
| Molecular Weight | 272.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(7-Bromo-5-fluoro-1H-indol-3-yl)acetic acid (C10H7BrFNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies 2-(7-Bromo-5-fluoro-1H-indol-3-yl)acetic acid (CAS 1227598-38-0), a certified reference material (molecular formula C10H7BrFNO2, MW 272.07 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7BrFNO2 |
| Molecular Weight | 272.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 5-Bromo-7-fluoroindole-3-acetic Acid (CAS 1019111-81-9)
- 2-(4-Bromo-2-fluorophenyl)-1,2-dihydro-5-methyl-3H-1,2,4-triazol-3-one (CAS 111992-09-7)
- 4-Bromo-2,3-difluorobenzenesulfonamide (CAS 1133123-01-9)
- 2-(7-Bromo-4-fluoro-1H-indol-3-yl)acetic acid (CAS 1227496-22-1)
- 2-(6-Bromo-4-fluoro-1H-indol-3-yl)acetic acid (CAS 1227502-64-8)
- 2-(6-Bromo-5-fluoro-1H-indol-3-yl)acetic acid (CAS 1227563-84-9)
- 2-(5-Bromo-6-fluoro-1H-indol-3-yl)acetic acid (CAS 1227576-93-3)
- 4-Bromo-7-fluoroindole-3-acetic Acid (CAS 1227598-12-0)
Recommended Standards
- (1-(4-Bromo-2-fluorophenyl)-1H-1,2,3-triazol-4-yl)methanol (CAS 1247801-56-4)
- (1-(2-Bromo-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methanol (CAS 1248968-81-1)
- 4,6-Dichloro-2-(methylsulfonyl)-5-nitropyrimidine (CAS 127726-62-9)
- 2-(4-(Difluoromethyl)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1310949-75-7)
- 1-(2-Chloroethanesulfonyl)-4-nitrobenzene (CAS 6461-63-8)
- Ethyl 5-chloro-1-methyl-1H-indole-2-carboxylate (CAS 59908-53-1)
- Ethyl 4-(piperidine-2-carboxamido)butanoate hydrochloride (CAS 1604641-88-4)
- 2-Allyl-5-methylthiophene (CAS 69485-38-7)
- N-(4-(2-fluorophenyl)piperazine-1-carbonothioyl)-4-methylbenzamide (CAS 497061-04-8)
- 9-Hydroxy-9H-xanthene-9-carboxylic acid (CAS 6309-32-6)
- 2',4',6'-Trimethyl-5'-phenyl-1,1':3',1''-terphenyl (CAS 6231-26-1)
- N-(2-Cyanobenzo[d]thiazol-5-yl)acetamide (CAS 646035-19-0)
- Metamizole free (CAS 50567-35-6)
- Fibronectin Adhesion-Promoting Peptide (CAS 125720-21-0)
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