4-(Bromomethyl)-3-chloro-5-fluoropyridine CAS 1227563-95-2

Purity 97%+In StockPharmaceutical Standards
CAS No.1227563-95-2
Molecular FormulaC6H4BrClFN
Molecular Weight224.46 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

4-(Bromomethyl)-3-chloro-5-fluoropyridine CAS 1227563-95-2 chemical structure

Description

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

4-(Bromomethyl)-3-chloro-5-fluoropyridine (CAS 1227563-95-2), molecular formula C6H4BrClFN and molecular weight 224.46 g/mol, is a CATO reference standard with documented purity and traceability.

Structurally, 4-(Bromomethyl)-3-chloro-5-fluoropyridine (C6H4BrClFN) contains a nitrile group, fluorine/chlorine/bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 224.46 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC6H4BrClFN
Molecular Weight224.46 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1990
Halogen ContentF/Cl/Br-containing
Nitrogen Atoms1

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