4-Iodo-3-(trifluoromethyl)pyridin-2-amine CAS 1227581-85-2
| CAS No. | 1227581-85-2 |
| Molecular Formula | C6H4F3IN2 |
| Molecular Weight | 288.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Iodo-3-(trifluoromethyl)pyridin-2-amine (CAS 1227581-85-2), molecular formula C6H4F3IN2 and molecular weight 288.01 g/mol, is a CATO reference standard with documented purity and traceability.
4-Iodo-3-(trifluoromethyl)pyridin-2-amine (C6H4F3IN2) contains a nitrile group, fluorine/iodine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Iodo-3-(trifluoromethyl)pyridin-2-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4F3IN2 |
| Molecular Weight | 288.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 2 |
Related Iodo Standards
- 2-Iodo-5-(trifluoromethyl)phenol (CAS 102771-00-6)
- 6-Iodo-2-(trifluoromethyl)pyridin-3-amine (CAS 1032507-24-6)
- 3-Iodo-5-(trifluoromethyl)phenol (CAS 1073339-06-6)
- 4-Iodo-2-(trifluoromethyl)phenol (CAS 1132942-88-1)
- 4-Iodo-6-(trifluoromethyl)pyridin-2-amine (CAS 1227581-86-3)
- 5-Iodo-6-(trifluoromethyl)pyridin-2-amine (CAS 1227596-12-4)
- 5-Iodo-2-(trifluoromethyl)pyridin-4-amine (CAS 1239462-10-2)
- 5-Iodo-2-(trifluoromethyl)phenol (CAS 1243312-81-3)
Recommended Standards
- 2-Amino-4-iodo-5-(trifluoromethyl)pyridine (CAS 1227515-42-5)
- 3-Amino-4-iodo-2-(trifluoromethyl)pyridine (CAS 1227509-56-9)
- 2-Amino-3-iodo-4-(trifluoromethyl)pyridine (CAS 1227602-87-0)
- 2-Amino-3-iodo-6-(trifluoromethyl)pyridine (CAS 1227602-97-2)
- Xanthophyll80% (CAS 180580-60-3)
- 1-(1-Carboxy-3-methylbutyl)-4,5-dimethyl-1h-imidazole 3-oxide (CAS 126263-09-0)
- tert-Butyl 2-formyloxyacetate (CAS 145641-58-3)
- (1h-Indol-3-yl)(3-(4-methoxyphenyl)oxiran-2-yl)methanone (CAS 15849-58-8)
- Dibenzo[b,e][1,4]dioxine-1-carbaldehyde (CAS 51689-41-9)
- 2,4,6-Trifluorophenylisothiocyanate (CAS 206761-91-3)
- 3-Nitro-2-[3-(2-phenyl-1,3-thiazol-5-yl)-1H-pyrazol-1-yl]pyridine (CAS 318255-94-6)
- 1-Ethyl 3-methyl piperidine-1,3-dicarboxylate (CAS 126291-63-2)
- 6-Chloro-2-(2-hydroxyphenyl)quinoline-4-carboxylic acid (CAS 669753-96-2)
- Crustacean Cardioactive Peptide (CCAP) (CAS 309247-84-5)
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