3-Chloro-4-(cyclopropylmethoxy)phenylboronic acid CAS 1228181-35-8
| CAS No. | 1228181-35-8 |
| Molecular Formula | C10H12BClO3 |
| Molecular Weight | 226.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-4-(cyclopropylmethoxy)phenylboronic acid (CAS 1228181-35-8) is a high-purity analytical reference standard with the molecular formula C10H12BClO3 and a molecular weight of 226.46 g/mol.
The molecular framework of 3-Chloro-4-(cyclopropylmethoxy)phenylboronic acid (C10H12BClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12BClO3 |
| Molecular Weight | 226.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- 2-Chloro-4-(cyclopropylmethoxy)phenylboronic acid (CAS 1824647-98-4)
- (2-Chloro-3-cyclopropyl-5-methoxyphenyl)boronic acid (CAS 2225176-26-9)
- (2-Chloro-4-cyclopropyl-5-methoxyphenyl)boronic acid (CAS 2225180-99-2)
- (2-Chloro-5-cyclopropyl-3-methoxyphenyl)boronic acid (CAS 2225169-13-9)
- (2-Chloro-5-cyclopropyl-4-methoxyphenyl)boronic acid (CAS 2225178-55-0)
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