(2-Chloro-5-cyclopropyl-3-methoxyphenyl)boronic acid CAS 2225169-13-9
| CAS No. | 2225169-13-9 |
| Molecular Formula | C10H12BClO3 |
| Molecular Weight | 226.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (2-Chloro-5-cyclopropyl-3-methoxyphenyl)boronic acid.
(2-Chloro-5-cyclopropyl-3-methoxyphenyl)boronic acid (CAS 2225169-13-9) is a high-purity analytical reference standard with the molecular formula C10H12BClO3 and a molecular weight of 226.46 g/mol.
(2-Chloro-5-cyclopropyl-3-methoxyphenyl)boronic acid (C10H12BClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (2-Chloro-5-cyclopropyl-3-methoxyphenyl)boronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12BClO3 |
| Molecular Weight | 226.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- 3-Chloro-4-(cyclopropylmethoxy)phenylboronic acid (CAS 1228181-35-8)
- 2-Chloro-4-(cyclopropylmethoxy)phenylboronic acid (CAS 1824647-98-4)
- (2-Chloro-3-cyclopropyl-5-methoxyphenyl)boronic acid (CAS 2225176-26-9)
- (2-Chloro-4-cyclopropyl-5-methoxyphenyl)boronic acid (CAS 2225180-99-2)
- (2-Chloro-5-cyclopropyl-4-methoxyphenyl)boronic acid (CAS 2225178-55-0)
- (4-Chloro-2-cyclopropyl-5-methoxyphenyl)boronic acid (CAS 2225155-83-7)
- (5-Chloro-6-(pyrrolidin-1-yl)pyridin-3-yl)boronic acid (CAS 1704121-31-2)
- (4-Chloro-2-cyclopentylpyrimidin-5-yl)boronic acid (CAS 2225172-39-2)
Recommended Standards
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- 1-(3-Isopropyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidine-4-carboxylic acid (CAS 1081114-28-4)
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