3-[(4-Chloro-2-fluorophenyl)(oxo)methyl]-6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazine CAS 1229236-83-2
| CAS No. | 1229236-83-2 |
| Molecular Formula | C19H17Cl2FN4O2 |
| Molecular Weight | 423.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-[(4-Chloro-2-fluorophenyl)(oxo)methyl]-6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazine.
3-[(4-Chloro-2-fluorophenyl)(oxo)methyl]-6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazine (CAS 1229236-83-2), molecular formula C19H17Cl2FN4O2 and molecular weight 423.27 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-[(4-Chloro-2-fluorophenyl)(oxo)methyl]-6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazine (C19H17Cl2FN4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-[(4-Chloro-2-fluorophenyl)(oxo)methyl]-6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H17Cl2FN4O2 |
| Molecular Weight | 423.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- (3E)-3-{[(2-chloro-4-fluorophenyl)methoxy]imino}-1-[2-(4-chlorophenyl)-1,3-thiazol-5-yl]propan-1-one (CAS 339279-43-5)
- 3-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1-[(1Z)-{[(4-chlorophenyl)methoxy]amino}methylidene]thiourea (CAS 339114-06-6)
- 4-Chloro-N'-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}ethanimidoyl)benzohydrazide (CAS 306976-83-0)
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- 2-Chloro-5-(2-(2-chloro-4-nitrophenoxy)acetamido)benzene-1-sulfonyl fluoride (CAS 25299-97-2)
- 3-Chloro-4-(2-(2-chloro-4-nitrophenoxy)acetamido)benzene-1-sulfonyl fluoride (CAS 25299-91-6)
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Recommended Standards
- 2-(3-(5-Bromopyrimidin-2-yl)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3(2H)-one (CAS 1100598-42-2)
- 1-(2,4-Dichloro-5-isopropoxyphenyl)-N-(4-fluorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide (CAS 400736-19-8)
- Ethyl 2-oxo-6-(trifluoromethyl)-3-(3-(trifluoromethyl)benzamido)-2H-pyran-5-carboxylate (CAS 400084-85-7)
- 1-(4-Iodophenyl)-3-[(4-methylphenyl)sulfanyl]pyrrolidine-2,5-dione (CAS 306732-15-0)
- 2-(2-Chloro-6-fluorophenyl)ethanol (CAS 214262-86-9)
- 2-(Isopropylamino)cyclohexan-1-ol (CAS 69592-28-5)
- 2-Acetoxy-propanÂe-1,2,3-tricarboxyÂlic acid-1,2-anhydride (CAS 58032-65-8)
- 1,2-Distearoyl-sn-glycerol (CAS 10567-21-2)
- N-((R)-2-(Diphenylphosphino)-1-phenylethyl)-N,2-dimethylpropane-2-sulfinamide (CAS 2757083-11-5)
- 4-Formylbenzo[d]oxazole-2-carboxamide (CAS 1806340-96-4)
- methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate;hydrochloride (CAS 156046-05-8)
- 4-(2-ethoxyphenoxy)piperidine hydrochloride (CAS 1197760-65-8)
- 1-Methyl-5-(2-morpholino-2-oxoethoxy)-1H-pyrazole-3-carboxylic acid (CAS 1240675-73-3)
- Q-Peptide trifluoroacetate salt (CAS 1361235-89-3)
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