Ruxolitinib Impurity 4 CAS 1236033-03-6
| CAS No. | 1236033-03-6 |
| Molecular Formula | C18H20N6O |
| Molecular Weight | 336.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ruxolitinib Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Ruxolitinib Impurity 4 (CAS 1236033-03-6) is a certified pharmaceutical impurity reference standard with the molecular formula C18H20N6O and a molecular weight of 336.39 g/mol.
Based on its molecular formula C18H20N6O, Ruxolitinib Impurity 4 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 336.39 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H20N6O |
| Molecular Weight | 336.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 6 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 22 (CAS CATO-C4X-205822)
- Ruxolitinib Impurity 7 (CAS CATO-C4X-20587)
- Ruxolitinib Impurity 85 (CAS CATO-C4X-205885)
- Ruxolitinib Impurity 99 (CAS CATO-C4X-205899)
- Ruxolitinib Impurity 31 (CAS CATO-C4X-205831)
- Ruxolitinib Impurity 234 (CAS CATO-C4X-2058234)
- Ruxolitinib impurity 51 (CAS CATO-C4X-205851)
- Ruxolitinib Impurity 231 (CAS CATO-C4X-2058231)
Recommended Standards
- Hydroxymethyl Ruxolitinib (CAS CATO-C4X-2058216)
- Cefoxitin EP Impurity C（Cefalotin EP Impurity D） (CAS 10590-10-0)
- Niraparib impurity 25 (CAS CATO-C4X-232925)
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