Emtricitabine Impurity 1 CAS 1238210-10-0
| CAS No. | 1238210-10-0 |
| Molecular Formula | C8H8FN3O4S |
| Molecular Weight | 261.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Emtricitabine Impurity 1 (CAS 1238210-10-0) is a certified pharmaceutical impurity reference standard with the molecular formula C8H8FN3O4S and a molecular weight of 261.23 g/mol.
Based on its molecular formula C8H8FN3O4S, Emtricitabine Impurity 1 contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 261.23 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H8FN3O4S |
| Molecular Weight | 261.23 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Emtricitabine Standards
- 5-epi Emtricitabine Carboxylic Acid (CAS CATO-C4X-123210)
- Emtricitabine Impurity 43 (CAS 6284-35-1)
- Emtricitabine impurity 50 (CAS CATO-C4X-123250)
- Emtricitabine Impurity 24 (CAS 1160303-44-5)
- Emtricitabine S-oxide(Mixture) (CAS 152128-77-3)
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- Emtricitabine impurity 42 (CAS 2101981-64-8)
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