Rivaroxaban Impurity 146 CAS 92632-81-0
| CAS No. | 92632-81-0 |
| Molecular Formula | C13H11NO5 |
| Molecular Weight | 261.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Rivaroxaban Impurity 146 (C13H11NO5) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Rivaroxaban Impurity 146 (CAS 92632-81-0, C13H11NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Rivaroxaban Impurity 146 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H11NO5 |
| Molecular Weight | 261.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Nitrogen Atoms | 1 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 143 (CAS CATO-C4X-1090143)
- Rivaroxaban Impurity 71 (CAS 811450-82-5)
- Rivaroxaban Ethyl Carbamate (CAS 1327778-39-1)
- Rivaroxaban Impurity 118 (CAS CATO-C4X-1090118)
- Rivaroxaban Impurity 212 (CAS CATO-C4X-1090212)
- Rivaroxaban Impurity 41 (CAS 1403383-56-1)
- Rivaroxaban Impurity 119 (CAS CATO-C4X-1090119)
- Rivaroxaban Impurity N6 (CAS 5466-93-3)
Recommended Standards
- 90429-09-7 4-Formyl-6-methoxy-3-nitrophenoxyacetic acid Acetic acid, (4-formyl-2-methoxy-5-nitrophenoxy)- 4-Fmnpaa (CAS 90429-09-7)
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