Vonoprazan Fumarate Impurity 2 CAS 1240948-77-9
| CAS No. | 1240948-77-9 |
| Molecular Formula | C11H7FN2 |
| Molecular Weight | 186.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Vonoprazan Fumarate Impurity 2 (CAS 1240948-77-9, C11H7FN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, Vonoprazan Fumarate Impurity 2 is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 186.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Vonoprazan Fumarate Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H7FN2 |
| Molecular Weight | 186.19 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Vonoprazan Standards
- Vonoprazan Impurity 207 (CAS 2304978-33-2)
- Vonoprazan Fumarate Impurity 50 (CAS CATO-C4X-102050)
- Vonoprazan Impurity 51 (CAS 1240949-51-2)
- Vonoprazan Impurity 204 (CAS 4810-41-7)
- Vonoprazan Fumarate Impurity 19 (CAS 161958-62-9)
- Vonoprazan Impurity 57 (CAS 2726830-13-1)
- Vonoprazan Fumarate Impurity 9 (CAS 14476-72-3)
- Vonoprazan Impurity 304 (CAS 57331-00-7)
Recommended Standards
- 54512-79-7 Benzo[1,2,5]thiadiazole-5,6-dicarbonitrile MFCD27964187 (CAS 54512-79-7)
- Ticarcillin Impurity 1 (CAS 50530-49-9)
- Thiophene-2,5-dicarboxylic acid monomethyl ester (CAS 38321-95-8)
- N-(5-Nitrothiophen-2-yl)acetamide (CAS 51419-40-0)
- Telmisartan Impurity 57 (CAS 884330-16-9)
- Arbidol Impurity 56 (CAS CATO-C4X-112956)
- Fluticasone Impurity 50 (CAS CATO-C4X-165050)
- (3-Chlorophenyl)(2,5-difluorobenzyl)sulfane (CAS 1443303-30-7)
- 2-Methyl-3,7-dihydro-2H-[1,2,3]triazolo[4,5-d]pyrimidine (CAS 58950-32-6)
- 2-(2-Chloro-5-fluorobenzofuran-3-yl)acetic acid (CAS 1420792-98-8)
- 3-Amino-5-(phenylcarbamoyl)phenylboronic acid (CAS 2096332-13-5)
- 1,1'-[Dithiobis(1-oxo-2,1-ethanediyl)]bis[glycylglycyl-glycine (CAS 174155-75-0)
- 4-Amino-6-(difluoromethyl)-5-nitropyridine-2-sulfonyl chloride (CAS 1806004-09-0)
- Semaglutide impurity 29 (CAS CATO-C4X-222629)
Why CATO?
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