Methylprednisolone Impurity 91 CAS 124106-96-3
| CAS No. | 124106-96-3 |
| Molecular Formula | C26H34O7 |
| Molecular Weight | 458.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Methylprednisolone Impurity 91 (CAS 124106-96-3, C26H34O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system, Methylprednisolone Impurity 91 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 458.54 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C26H34O7 |
| Molecular Weight | 458.54 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
Related Methylprednisolone Standards
- Methylprednisolone Impurity 53 (CAS CATO-C4X-191953)
- Methylprednisolone Impurity 68 (CAS 86413-24-3)
- Methylprednisolone impurity 97 (CAS CATO-C4X-191997)
- Methylprednisolone Hydrogen Succinate EP Impurity E (CAS 2920-86-7)
- Methylprednisolone Impurity 63 (CAS 7415-42-1)
- Methylprednisolone Impurity 73 (CAS CATO-C4X-191973)
- Methylprednisolone impurity 83 (CAS CATO-C4X-191983)
- Methylprednisolone Impurity 1 (CAS CATO-C4X-19191)
Recommended Standards
- Fumagillin (CAS 23110-15-8)
- Desonide 21-Acetate (CAS 25092-25-5)
- Triamcinolone Acetonide Impurity 46 (CAS CATO-C4X-132646)
- Cinobufotalin (CAS 1108-68-5)
- Apixaban Impurity 8 (CAS 1074549-87-3)
- Meptazinol Impurity 4 (CAS CATO-C4X-10304)
- Tedizolid Impurity 46 (CAS 171018-16-9)
- Methyl 2-(1,1-dioxidothiomorpholino)-3-phenylpropanoate (CAS 478040-49-2)
- Methyl 1-propyl-1H-pyrrole-2-carboxylate (CAS 70696-64-9)
- Methyl 2,5-difluoro-4-methoxybenzoate (CAS 1261830-21-0)
- (R)-4-(tert-butyl)-2-(pyrrolidin-2-yl)aniline (CAS 1213672-39-9)
- Mirogabalin impurity 71 (CAS CATO-C4X-292471)
- (S)-(-)-1-(4-Fluorophenyl)ethyl isocyanate (CAS 745783-74-8)
- Boc-Cholecystokinin Octapeptide (desulfated) (A-1295.0001) (CAS 25687-34-7)
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