6-Cyclopropyl-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-3-amine CAS 1242267-90-8
| CAS No. | 1242267-90-8 |
| Molecular Formula | C10H9F3N4 |
| Molecular Weight | 242.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
6-Cyclopropyl-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-3-amine (CAS 1242267-90-8), molecular formula C10H9F3N4 and molecular weight 242.20 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-Cyclopropyl-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-3-amine (C10H9F3N4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H9F3N4 |
| Molecular Weight | 242.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Cyclopropyl Standards
- 4-Cyclopropyl-6-(trifluoromethyl)-1h-pyrazolo[3,4-b]pyridin-3-amine (CAS 832739-88-5)
- 4-Cyclopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylic acid (CAS 1782798-37-1)
- N-Cyclopropyl 3-nitrobenzenesulfonamide (CAS 401589-92-2)
- N-Cyclopropyl 4-Nitrophenylsulfonamide (CAS 549476-61-1)
- N-Cyclopropyl-2-nitrobenzenesulfonamide (CAS 400839-43-2)
- n-Cyclopropyl-2-(quinolin-8-yloxy)acetamide (CAS 1147418-96-9)
- Methyl 5-cyclopropyl-1-phenylpyrazole-4-carboxylate (CAS 1150164-48-9)
- 1-Benzyl-3-cyclopropyl-1H-pyrazole-5-carboxylic acid (CAS 1239785-16-0)
Recommended Standards
- n-(3-Cyanobenzyl)-3,3,3-trifluoropropanamide (CAS 1240978-33-9)
- 2-((4-Fluoro-5-methyl-2-nitrophenyl)(methyl)amino)acetic acid (CAS 1251950-64-7)
- Ethyl 2-fluoro-4-(methylamino)-5-nitrobenzoate (CAS 1219119-52-4)
- (1-(Pyridin-3-yl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine (CAS 1255237-27-4)
- Tisocalcitate (CAS 156965-06-9)
- 2-Bromo-4-chloro-5-(difluoromethyl)pyridine (CAS 1805018-95-4)
- 4-(3-Chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (CAS 314000-19-6)
- 6-Fluoro-2-methylnicotinonitrile (CAS 375368-85-7)
- Afoxolaner Impurity 13 (CAS 1125727-10-7)
- 1-((6-Methoxypyridin-2-yl)methyl)-1h-1,2,3-triazol-4-amine (CAS 1501365-54-3)
- For-Nle-Leu-Phe-OH (CAS 61864-82-2)
- 6-Fluorospiro[isochromane-1,4'-piperidine] (CAS 866029-31-4)
- 5H,6H,7H,8H,9H-[1,2,3,4]tetrazolo[1,5-a]azepin-7-ylmethanol (CAS 1936339-83-1)
- Fibrinogen-Binding Inhibitor Peptide (CAS 89105-94-2)
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