5-(Chloromethyl)-1-(4-fluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid CAS 1242268-20-7
| CAS No. | 1242268-20-7 |
| Molecular Formula | C10H7ClFN3O2 |
| Molecular Weight | 255.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(Chloromethyl)-1-(4-fluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid.
5-(Chloromethyl)-1-(4-fluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid (CAS 1242268-20-7) is a high-purity analytical reference standard with the molecular formula C10H7ClFN3O2 and a molecular weight of 255.63 g/mol.
5-(Chloromethyl)-1-(4-fluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid (C10H7ClFN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-(Chloromethyl)-1-(4-fluorophenyl)-1H-1,2,4-triazole-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7ClFN3O2 |
| Molecular Weight | 255.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloromethyl Standards
- Methyl 2-(chloromethyl)-7-methoxy-1,3-benzoxazole-5-carboxylate (CAS 1221792-62-6)
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- Ethyl 5-(chloromethyl)-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 1118787-44-2)
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- 5-(Chloromethyl)-2-(diethylamino)-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one (CAS 1708080-02-7)
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Recommended Standards
- 1-[(3-Chloro-4-fluorophenyl)methyl]-4-nitro-1h-pyrazole (CAS 1240579-43-4)
- 1-(2-Chloro-4-fluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1338667-00-7)
- 1-[(3-Chloro-2-fluorophenyl)methyl]-4-nitro-1h-pyrazole (CAS 1240579-31-0)
- 5-Chloro-1-(2-fluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1355216-40-8)
- Ethyl 2-(2-amino-2,3-dihydro-1h-inden-2-yl)acetate (CAS 917460-33-4)
- methyl 4-methyl-1H-pyrrole-2-carboxylate (CAS 34402-78-3)
- N-(2-Chloroethyl)methanesulfonamide (CAS 21896-59-3)
- ethyl 1-(5-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate (CAS 1909309-82-5)
- (3R,5S)-5-Methylpyrrolidin-3-ol (CAS 1108234-23-6)
- 6-Methyl-5-nitro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (CAS 1000340-25-9)
- 2-(Methyl(4-phenylquinazolin-2-yl)amino)ethan-1-ol (CAS 924060-48-0)
- n-(Benzo[b]thiophen-3-ylmethyl)butan-2-amine (CAS 1250836-66-8)
- 2-(Furan-3-yl)butanoic acid (CAS 1343336-44-6)
- Pancreatic Polypeptide (bovine) (CAS 179986-89-1)
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