Balsalazide impurity 8 CAS 1242567-07-2
| CAS No. | 1242567-07-2 |
| Molecular Formula | C14H10N2O5 |
| Molecular Weight | 286.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Balsalazide impurity 8.
Balsalazide impurity 8 (CAS 1242567-07-2) is a certified pharmaceutical impurity reference standard with the molecular formula C14H10N2O5 and a molecular weight of 286.24 g/mol.
The molecular framework of Balsalazide impurity 8 (C14H10N2O5) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H10N2O5 |
| Molecular Weight | 286.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 2 |
Related Balsalazide Standards
- Balsalazide Impurity 1 (CAS 59642-21-6)
- Balsalazide-d3 (CAS 1246834-21-8)
- Balsalazide-d (CAS 80573-04-2)
- Balsalazide 3-Isomer (CAS 1242567-09-4)
- Balsalazide Impurity 9 (CAS 1798395-96-6)
- Balsalazide Impurity 31 (CAS 13135-92-7)
- Balsalazide Impurity 2 (CAS 7377-08-4)
- Balsalazide Impurity 6 (CAS 1346606-13-0)
Recommended Standards
- Benserazide impurity 39 (CAS CATO-C4X-142739)
- Inosine impurity 4 (CAS 126222-04-6)
- Ribavirin EP Impurity F (CAS 58151-87-4)
- Benzaldehyd-2,4-dinitrophenylhydrazone (CAS 1157-84-2)
- Tirzepatide Impurity 59 (CAS CATO-C4X-324059)
- Riociguat Impurity N20 (CAS 256499-19-1)
- Roxadustat Impurity 26 (CAS 2711953-58-9)
- 2,5-Dihydro-3-(hydroxymethyl)-2,2,5,5-tetramethyl-4-(3-pyridinyl)-1H-pyrrol-1-yloxy (CAS 1379779-17-5)
- Methyl 6-cyano-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-4-carboxylate (CAS 1190312-61-8)
- Chromeazurol B (CAS 1796-92-5)
- Methyl 6-phenyl-4-(trifluoromethyl)-7-azaindole-2-carboxylate (CAS 1146081-24-4)
- Methyl 3,5-dibromo-2-fluorobenzoate (CAS 537658-08-5)
- 1-Bromo-2-(cyclohexyloxy)benzene (CAS 105902-37-2)
- Tetrapeptide-3 (CAS 827306-97-8)
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