5-Hydroxy-2-(trifluoromethyl)benzoic acid CAS 1243373-31-0
| CAS No. | 1243373-31-0 |
| Molecular Formula | C8H5F3O3 |
| Molecular Weight | 206.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Hydroxy-2-(trifluoromethyl)benzoic acid.
5-Hydroxy-2-(trifluoromethyl)benzoic acid (CAS 1243373-31-0) is a high-purity analytical reference standard with the molecular formula C8H5F3O3 and a molecular weight of 206.12 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 5-Hydroxy-2-(trifluoromethyl)benzoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 206.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 5-Hydroxy-2-(trifluoromethyl)benzoic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H5F3O3 |
| Molecular Weight | 206.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Hydroxy Standards
- 4-Hydroxy-2-(trifluoromethoxy)benzaldehyde (CAS 1017083-37-2)
- 2-Hydroxy-4-(trifluoromethoxy)benzaldehyde (CAS 1071156-25-6)
- 2-Hydroxy-6-(trifluoromethyl)nicotinamide (CAS 116548-03-9)
- 3-Hydroxy-4-(trifluoromethoxy)benzaldehyde (CAS 1208078-41-4)
- 2-Hydroxy-2-(2,3,4-trifluorophenyl)acetic acid (CAS 1214332-27-0)
- 2-Hydroxy-6-(trifluoromethoxy)benzaldehyde (CAS 1261500-70-2)
- 5-Hydroxy-2-(trifluoromethoxy)benzaldehyde (CAS 1261584-14-8)
- 3-Hydroxy-5-(trifluoromethoxy)benzaldehyde (CAS 1261852-80-5)
Recommended Standards
- 3-Amino-2-(trifluoromethyl)isonicotinic acid (CAS 1227598-54-0)
- 5-Amino-2-(trifluoromethyl)pyridine-3-carboxylic acid (CAS 1245913-77-2)
- 2-Amino-3-(trifluoromethyl)isonicotinic acid (CAS 1227582-09-3)
- Desacetyl Triflusal-13C6 (CAS 1246817-12-8)
- 5-Hydrazono-1,4-dimethyl-4,5-dihydro-1H-1,2,4-triazole (CAS 754201-45-1)
- 2,4-Dichloro-6-(difluoromethyl)pyrimidine (CAS 1706464-39-2)
- 6-Cyano-5-(difluoromethyl)-4-fluoropyridine-3-sulfonamide (CAS 1806911-39-6)
- 1-(2-Bromophenyl)-2-phenylethan-1-one (CAS 36081-66-0)
- 4-[(2,6-Dichlorobenzyl)oxy]benzoyl chloride (CAS 1160250-95-2)
- 1-Iodo-3,5-dimethylcyclohexane (CAS 87621-26-9)
- 1-(2,4,6-Trifluorophenyl)cyclopentanol (CAS 1512450-66-6)
- Ropivacaine EP Impurity C (CAS 24358-84-7)
- 3,5-Difluoro-4-methoxyaniline hydrochloride (CAS 62106-10-9)
- Semaglutide impurity 41 (CAS CATO-C4X-222641)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com