5-Chloro-3-(2-trimethylsilylethynyl)pyrazin-2-amine CAS 1244776-64-4
| CAS No. | 1244776-64-4 |
| Molecular Formula | C9H12ClN3Si |
| Molecular Weight | 225.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-Chloro-3-(2-trimethylsilylethynyl)pyrazin-2-amine (C9H12ClN3Si) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies 5-Chloro-3-(2-trimethylsilylethynyl)pyrazin-2-amine (CAS 1244776-64-4), a certified reference material (molecular formula C9H12ClN3Si, MW 225.75 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H12ClN3Si |
| Molecular Weight | 225.75 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 7-Chloro-2-(trimethylsilyl)furo[3,2-b]pyridine (CAS 1071540-51-6)
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- 6-Chloro-2-(trimethylsilyl)furo[3,2-b]pyridine (CAS 1186310-77-9)
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