2-(Trifluoromethyl)piperidin-4-one CAS 1245648-26-3
| CAS No. | 1245648-26-3 |
| Molecular Formula | C6H8F3NO |
| Molecular Weight | 167.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Trifluoromethyl)piperidin-4-one (CAS 1245648-26-3), molecular formula C6H8F3NO and molecular weight 167.13 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(Trifluoromethyl)piperidin-4-one (C6H8F3NO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(Trifluoromethyl)piperidin-4-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H8F3NO |
| Molecular Weight | 167.13 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 3-(Trifluoromethyl)piperidin-2-one (CAS 1000934-03-1)
- 7-(Trifluoromethyl)-2-oxa-5-azabicyclo[4.1.0]Heptane (CAS 1235528-17-2)
- 6-(trifluoromethyl)piperidin-2-one (CAS 1394040-82-4)
- 1-(Trifluoromethyl)-2-oxa-6-azaspiro[3.3]heptane (CAS 1454909-15-9)
- 4-(Trifluoromethyl)piperidin-2-one (CAS 1803588-50-2)
- 5-(Trifluoromethyl)piperidin-2-one (CAS 50549-24-1)
- 6-(Trifluoromethyl)-1,4,5,6-tetrahydropyrimidin-2-amine (CAS 794477-74-0)
- 2-Methyl-4-(trifluoromethyl)thiazole (CAS 137929-13-6)
Recommended Standards
- (S)-1-(4,5-Dihydrofuran-3-yl)-2,2,2-trifluoroethan-1-amine (CAS 1260591-58-9)
- 1-(2,2,2-Trifluoroethyl)pyrrolidin-3-one (CAS 1096881-58-1)
- (E)-4-(Dimethylamino)-1,1,1-trifluoro-3-buten-2-one (CAS 127223-93-2)
- (1R,6S,7S)-7-(trifluoromethyl)-2-oxa-5-azabicyclo[4.1.0]Heptane (CAS 1305712-30-4)
- 8-Ethyl-4-[3-(trifluoromethyl)benzoyl]-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326812-39-8)
- 2-Hydroxy-3-methoxyphenylacetonitrile (CAS 42973-56-8)
- 1-(Chloromethyl)-2-(3,3,3-trifluoropropoxy)benzene (CAS 1338954-37-2)
- 5-Methoxy-3H-spiro[isobenzofuran-1,4'-piperidin]-3-one (CAS 180160-90-1)
- Benzyl ((1-(2-aminoacetyl)piperidin-2-yl)methyl)(methyl)carbamate (CAS 1353946-79-8)
- 3-(4-Pyridyl)propyl Acetate (CAS 38456-25-6)
- 4-Chloro-6-(difluoromethyl)-3-fluoro-2-methoxypyridine (CAS 1805390-66-2)
- (4-Bromo-5-methylisoxazol-3-yl)methanol (CAS 1040278-91-8)
- 1,2-O-(1-Methylethylidene)-α-D-allofuranose (CAS 4495-04-9)
- Insulin B (22-25) (CAS 34367-73-2)
Why CATO?
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