2-Methyl-2-(pyrimidin-5-yl)propanoic acid CAS 1248288-05-2
| CAS No. | 1248288-05-2 |
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 166.18 g/mol gives 2-Methyl-2-(pyrimidin-5-yl)propanoic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-Methyl-2-(pyrimidin-5-yl)propanoic acid (CAS 1248288-05-2), molecular formula C8H10N2O2 and molecular weight 166.18 g/mol, is a CATO reference standard with documented purity and traceability.
2-Methyl-2-(pyrimidin-5-yl)propanoic acid (C8H10N2O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 2 |
Related Methyl Standards
- Ethyl 2-(pyrimidin-4-yl)acetate (CAS 1240606-58-9)
- Methyl 2-(pyrimidin-5-yl)propanoate (CAS 1250731-02-2)
- 2-Methyl-3-(pyrimidin-2-yl)propanoic acid (CAS 819850-14-1)
- 2-Methyl-3-(pyrimidin-4-yl)propanoic acid (CAS 819850-15-2)
- ethyl 2-(pyrimidin-5-yl)acetate (CAS 6214-48-8)
- Methyl 3-(pyrimidin-4-yl)propanoate (CAS 2435-42-9)
- Methyl 3-(pyrimidin-5-yl)propanoate (CAS 224776-16-3)
- N1-(Pyrimidin-2-yl)butane-1,4-diamine (CAS 223494-30-2)
Recommended Standards
- N-((5-Methylisoxazol-3-yl)methyl)acrylamide (CAS 1248224-66-9)
- 5-Cyclopropyl-N-methylisoxazole-4-carboxamide (CAS 124845-01-8)
- 1-(1-Methyl-1h-pyrazol-4-yl)butane-1,3-dione (CAS 1247584-05-9)
- Methyl 2-cyclopropyl-1h-imidazole-4-carboxylate (CAS 1250136-57-2)
- 4-(Prop-2-en-1-yl)aniline (CAS 32704-23-7)
- (4-Bromo-2-chlorophenyl)(4-chlorophenyl)methanone (CAS 1157395-92-0)
- 4,4-Dimethyl-4,5-dihydrothiazol-2-amine hydrochloride (CAS 2271475-38-6)
- 2-Hydrazinyl-5-(pyrrolidine-1-sulfonyl)pyridine (CAS 627843-11-2)
- Methyl 4-chloro-2-(trifluoromethyl)thieno[3,4-b]pyridine-7-carboxylate (CAS 175203-40-4)
- 5-(4-(Trifluoromethoxy)phenyl)nicotinaldehyde (CAS 887973-59-3)
- Methyl({1-[2-(trifluoromethyl)phenyl]propan-2-yl})amine (CAS 1344274-22-1)
- Boc-D-Alg(Boc)2-OH (CAS 1931922-99-4)
- 7-Hydroxyquinoline-4-carboxylic acid (CAS 1017969-32-2)
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