1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-ol CAS 1250351-66-6
| CAS No. | 1250351-66-6 |
| Molecular Formula | C12H12FNOS |
| Molecular Weight | 237.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-ol (CAS 1250351-66-6), molecular formula C12H12FNOS and molecular weight 237.29 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution, 1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-ol is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 237.29 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12FNOS |
| Molecular Weight | 237.29 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related fluorophenyl Standards
- 1-[2-(2-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-ol (CAS 1250706-48-9)
- 4-Ethyl-3-(2-fluorophenyl)-5-(methylthio)-4H-1,2,4-triazole (CAS 116850-64-7)
- 4-Ethyl-3-(4-fluorophenyl)-5-(methylthio)-4H-1,2,4-triazole (CAS 868255-87-2)
- 2-(2-Fluorophenyl)-2-(piperidin-1-yl)acetic acid (CAS 1017206-15-3)
- 1-[(3-fluorophenyl)methyl]piperidine-2-carboxylic acid (CAS 1031317-91-5)
- 2-(4-Fluorophenyl)-1-(3-hydroxypiperidin-1-yl)ethan-1-one (CAS 1088192-24-8)
- 1-[1-(4-fluorophenyl)ethyl]-3-hydroxypiperidin-2-one (CAS 1186046-94-5)
- Methyl 5-(2-fluorophenyl)piperidine-3-carboxylate (CAS 1203796-73-9)
Recommended Standards
- Tert-butyl n-[1-(3-hydroxyphenyl)ethyl]carbamate (CAS 1246210-72-9)
- 2-(tert-Butoxy)-3-cyclopropoxy-4-methoxypyridine (CAS 1243481-30-2)
- 2-Methoxy-N-(1-(p-tolyloxy)propan-2-yl)acetamide (CAS 1252160-18-1)
- 3-(tert-Butoxy)-5-cyclopropoxy-4-methoxypyridine (CAS 1243464-42-7)
- 5-(2-Hydroxyethyl)-3,4-dimethylthiazol-3-ium (CAS 54379-31-6)
- 4-Methyl-1-oxa-4-azaspiro[4.5]decane (CAS 39931-24-3)
- 5-methoxy-1-methyl-1H-pyrazol-3-amine hydrochloride (CAS 1798013-55-4)
- (1S,2R)-2-Methylcyclopropane-1-carboxamide (CAS 1821757-62-3)
- Duloxetine Impurity 56 HCl (CAS 1798887-69-0)
- 2-(4-Methoxyphenyl)-4,6-bis(trichloromethyl)-1,3,5-triazine (CAS 3584-23-4)
- Nir-667n-succinimidylester (CAS 151134-79-1)
- 5-(2-Nitrophenyl)-3H-1,3,4-oxadiazol-2-one (CAS 83725-79-5)
- Rac-Timolol Maleate (CAS 57073-55-9)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
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