(4-Chloro-3-fluorophenyl)methanesulfonyl chloride CAS 1250404-82-0
| CAS No. | 1250404-82-0 |
| Molecular Formula | C7H5Cl2FO2S |
| Molecular Weight | 243.08 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
(4-Chloro-3-fluorophenyl)methanesulfonyl chloride (CAS 1250404-82-0), molecular formula C7H5Cl2FO2S and molecular weight 243.08 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (4-Chloro-3-fluorophenyl)methanesulfonyl chloride (C7H5Cl2FO2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C7H5Cl2FO2S |
| Molecular Weight | 243.08 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 2-Chloro-4-fluoro-5-methylbenzene-1-sulfonyl chloride (CAS 1208076-71-4)
- (3-Chloro-4-fluorophenyl)methanesulfonyl chloride (CAS 1211516-98-1)
- 5-Chloro-4-fluoro-2-methylbenzene-1-sulfonyl chloride (CAS 1242339-40-7)
- (4-Chloro-2-fluorophenyl)methanesulfonyl chloride (CAS 1308384-53-3)
- (2-Chloro-5-fluorophenyl)methanesulfonyl chloride (CAS 1308384-59-9)
- (3-Chloro-2-fluorophenyl)methanesulfonyl chloride (CAS 1314905-61-7)
- (5-Chloro-2-fluorophenyl)methanesulfonyl chloride (CAS 1314961-07-3)
- 2-Chloro-6-fluoro-3-methylbenzenesulfonyl chloride (CAS 1706430-38-7)
Recommended Standards
- 5-Bromo-1-ethyl-6-fluoro-1H-benzo[d]imidazole (CAS 1261988-22-0)
- 6-Bromo-4-fluoro-1,3-dimethyl-1H-indazole (CAS 1214900-64-7)
- 2-(5-Bromo-2-fluorophenyl)-2-(methylamino)acetonitrile (CAS 1152577-89-3)
- 7-Bromo-2,1,3-benzothiadiazole-4-carboxaldehyde (CAS 1071224-34-4)
- 6'-O-Β-D-Glucosylgentiopicroside (CAS 115713-06-9)
- (S)-1-(2,4-Dimethoxyphenyl)ethan-1-amine hydrochloride (CAS 1929526-23-7)
- 2-(6-(3-Propyl-1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)acetic acid (CAS 1355175-54-0)
- 1-[2-[(4-Methoxyphenyl)methoxy]phenyl]ethanone (CAS 371258-91-2)
- 5-(3,5-Difluorophenyl)-1,3-oxazole (CAS 1235340-39-2)
- Isavuconazole Impurity 223 (CAS CATO-C4X-1236223)
- 6-(4-Bromophenyl)picolinaldehyde (CAS 65219-26-3)
- 1-Ethyl-2-fluoro-4-methoxy-5-nitrobenzene (CAS 1089282-52-9)
- Hexaamminenickel(II) bromide (CAS 13601-55-3)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
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