Abemaciclib Impurity 52 CAS 1250947-20-6
| CAS No. | 1250947-20-6 |
| Molecular Formula | C12H18ClN3 |
| Molecular Weight | 239.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Abemaciclib Impurity 52 (CAS 1250947-20-6, C12H18ClN3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Abemaciclib Impurity 52 is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 239.74 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Abemaciclib Impurity 52 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H18ClN3 |
| Molecular Weight | 239.74 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Abemaciclib Standards
- Abemaciclib Impurity 173 (CAS CATO-C4X-2937173)
- Abemaciclib Impurity 83 (CAS 1508701-56-1)
- Abemaciclib Impurity 67 (CAS CATO-C4X-293767)
- Abemaciclib Impurity 39 (CAS 2346512-66-9)
- Abemaciclib Impurity 175 (CAS CATO-C4X-2937175)
- Abemaciclib Impurity 91 (CAS 937605-75-9)
- Abemaciclib impurity 118 (CAS CATO-C4X-2937118)
- Abemaciclib Impurity 38 (CAS CATO-C4X-293738)
Recommended Standards
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com