Nebivolol Impurity 35 CAS 1199945-26-0
| CAS No. | 1199945-26-0 |
| Molecular Formula | C29H31F2NO4 |
| Molecular Weight | 495.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Nebivolol Impurity 35 (CAS 1199945-26-0, C29H31F2NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nebivolol Impurity 35 (C29H31F2NO4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C29H31F2NO4 |
| Molecular Weight | 495.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity N1 (CAS 929706-85-4)
- Nebivolol Impurity 97 (CAS CATO-C4X-196897)
- Nebivolol Impurity 99 (CAS CATO-C4X-196899)
- Nebivolol-D6 N-Nitroso (CAS CATO-C4X-1968102)
- Nebivolol Impurity 39 (CAS CATO-C4X-196839)
- Nebivolol Impurity 41 (CAS CATO-C4X-196841)
- Nebivolol Impurity 1 (Mixture of Diastereomers) (CAS CATO-C4X-19681)
- Nebivolol Impurity 91 (CAS CATO-C4X-196891)
Recommended Standards
- Rosuvastatin Impurity 36 (CAS 147118-40-9)
- Oxodesmosine (CAS 147044-49-3)
- Octyl 2-acetamido-2-deoxy-3-O-(b-D-galactopyranosyl)-α-D-glucopyranoside (CAS 607353-49-1)
- (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butoxycarbonyl)piperazin-1-yl)propanoic acid (CAS 2044710-23-6)
- Sunitinib Impurity 83 (CAS CATO-C4X-133383)
- CAS 31264-06-9 (CAS 31264-06-9)
- Atorvastatin Impurity 26 (CAS 444577-70-2)
- Ethyl 4,5-dioxopyrrolidine-3-carboxylate (CAS 59226-20-9)
- 4-Amino-1H-indazole-6-carboxylic acid (CAS 885519-89-1)
- 4-Nitrobenzyl 1-Thio-β-D-glucopyranoside (CAS 35785-17-2)
- 6-Bromo Nicotinic Acid Ethyl Ester (CAS 132334-98-6)
- Vericiguat impurity 45 (CAS CATO-C4X-289645)
- L-erythro-Ritalinic Acid-d10 (Major) (CAS 1330166-48-7)
- Semaglutide impurity 94 (CAS CATO-C4X-222694)
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