3-Amino-1-(4-chloro-3-fluorophenyl)pyrrolidin-2-one CAS 1251344-72-5
| CAS No. | 1251344-72-5 |
| Molecular Formula | C10H10ClFN2O |
| Molecular Weight | 228.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-Amino-1-(4-chloro-3-fluorophenyl)pyrrolidin-2-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 3-Amino-1-(4-chloro-3-fluorophenyl)pyrrolidin-2-one (CAS 1251344-72-5), a certified reference material (molecular formula C10H10ClFN2O, MW 228.65 g/mol) for analytical method development and quality control.
3-Amino-1-(4-chloro-3-fluorophenyl)pyrrolidin-2-one (C10H10ClFN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Amino-1-(4-chloro-3-fluorophenyl)pyrrolidin-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H10ClFN2O |
| Molecular Weight | 228.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 3-Amino-1-(4-chloro-2-fluorophenyl)pyrrolidin-2-one (CAS 1249730-95-7)
- 3-Amino-1-(3-chloro-4-fluorophenyl)pyrrolidin-2-one (CAS 192318-48-2)
- Methyl 8-amino-5-chloro-2,3-dihydroimidazo[1,2-c]pyrimidine-7-carboxylate (CAS 106350-23-6)
- 4-(4-Amino-6-chloro-1,3,5-triazin-2-yl)piperazin-2-one (CAS 1220029-47-9)
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Recommended Standards
- 1-(3-Chloro-4-fluorophenyl)cyclobutanecarboxylic Acid (CAS 1260672-26-1)
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