4-tert-Butyldimethylsilyl-4a’-hydroxy Simvastatin CAS 125142-16-7
| CAS No. | 125142-16-7 |
| Molecular Formula | C31H54O6Si |
| Molecular Weight | 550.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4-tert-Butyldimethylsilyl-4a’-hydroxy Simvastatin meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
4-tert-Butyldimethylsilyl-4a’-hydroxy Simvastatin (CAS 125142-16-7) is a high-purity analytical reference standard with the molecular formula C31H54O6Si and a molecular weight of 550.84 g/mol.
The molecular framework of 4-tert-Butyldimethylsilyl-4a’-hydroxy Simvastatin (C31H54O6Si) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C31H54O6Si |
| Molecular Weight | 550.84 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
Related tert Standards
- 3-(3-((tert-Butyldimethylsilyl)oxy)-2,2-dimethylpropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole (CAS 2057515-03-2)
- 5-(3-((tert-Butyldimethylsilyl)oxy)-2,2-dimethylpropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole (CAS 2057515-07-6)
- 1-(Tert-butyldimethylsilyl)-5-(tributylstannyl)-1H-pyrrolo[2,3-b]pyridine (CAS 754214-65-8)
- 4-tert-Butyldimethylsilyl-5-chloro-6-oxo Simvastatin (CAS 134395-20-3)
- 4-tert-Butyldimethylsilyl-5'-chloro-4a'-hydroxy simvastatin (CAS 123852-10-8)
- 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (CAS 174264-46-1)
- 6-tert-Butyldimethylsilyl-4'-hydroxy Raloxifene (CAS 174264-47-2)
- 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene-d4 (CAS 1189422-34-1)
Recommended Standards
- RTI-82, >98% (HPLC) (CAS 141782-67-4)
- TPB26 (CAS 1392832-45-9)
- 1-(5-((4-Chlorophenyl)thio)-4-(2,4-dichlorophenyl)thiazol-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (CAS 956729-65-0)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[(2-{[(2,6-dichlorophenyl)methyl]sulfanyl}-1-methyl-1H-imidazol-5-yl)methyl]piperazine (CAS 338422-48-3)
- 5-Bromo-1H-imidazo[4,5-b]pyrazin-2(3H)-one (CAS 1260763-85-6)
- Ethyl 6-Methylindole-3-acetate (CAS 1783325-62-1)
- 2-((2-(4-Chlorophenyl)-2-oxoethyl)thio)-4-(4-methoxyphenyl)-6-phenylnicotinonitrile (CAS 332100-84-2)
- Sumatriptan-d (CAS 1346603-68-6)
- (S)-N-Ethyl-1-methylpyrrolidin-3-amine (CAS 1354017-51-8)
- trans,trans-4'-Butylbicyclohexyl-4-carboxylic Acid (CAS 89111-63-7)
- 2-[2-[(5-Amino-1,3,4-thiadiazol-2-yl)thio]ethyl]-1H-isoindole-1,3(2H)-dione (CAS 556024-08-9)
- 4-(1-Hydroxyethyl)picolinonitrile (CAS 1554454-22-6)
- Tert-butyl 6-cyano-5-methyl-3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 1165923-92-1)
- Insulin Lispro (CAS 133107-64-9)
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