Clopidogrel Impurity 90 CAS 1251736-86-3
| CAS No. | 1251736-86-3 |
| Molecular Formula | C16H13ClNO2S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Clopidogrel Impurity 90 (CAS 1251736-86-3) is a certified pharmaceutical impurity reference standard with the molecular formula C16H13ClNO2SBr and a molecular weight of 398.70 g/mol.
Clopidogrel Impurity 90 (C16H13ClNO2SBr) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H13ClNO2S Br |
| Molecular Weight | 398.70 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Clopidogrel Standards
- Clopidogrel Impurity 74 (CAS 1008008-56-7)
- Clopidogrel Impurity 82 (CAS 1015247-87-6)
- rac-Clopidogrel EP Impurity A HCl (CAS 1015247-88-7)
- rac Clopidogrel [(tert-Butylcarbonyl)oxy]methyl ester (CAS 1043913-82-1)
- 2-Oxo Clopidogrel (Mixture of Diastereomers) (CAS 109904-27-0)
- Clopidogrel Impurity 42 (CAS 109904-36-1)
- cis-Clopidogrel glutathione disulfide, mixture of diastereomers (CAS 1118605-95-0)
- Clopidogrel Impurity 48 (CAS 111954-31-5)
Recommended Standards
- Carbocisteine Impurity 54 TFA (CAS 21885-10-9)
- Iopromide Impurity 12 (CAS CATO-C4X-183212)
- Pinaverium Bromide Impurity 43 (CAS 175844-54-9)
- Dabigatran Impurity 109 (CAS CATO-C4X-1089109)
- 2-(Propylamino)benzoic acid (CAS 21716-81-4)
- (3S,5S)-5-(trifluoromethyl)piperidin-3-ol (CAS 2306245-31-6)
- 2-Methylquinazoline-4-carbonitrile (CAS 65078-93-5)
- 2,5-Dichloro-N-(2-(ethylamino)ethyl)benzenesulfonamide hydrochloride (CAS 1591636-22-4)
- n-(1-(4-Chlorophenyl)ethyl)propan-2-amine (CAS 1021091-71-3)
- Calcium-Like Peptide 3 (CAS 261969-05-5)
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