7-Methoxy-2-(pyrrolidin-1-yl)-3-[3-(trifluoromethyl)phenyl]quinoline CAS 1252003-94-3
| CAS No. | 1252003-94-3 |
| Molecular Formula | C21H19F3N2O |
| Molecular Weight | 372.38 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-Methoxy-2-(pyrrolidin-1-yl)-3-[3-(trifluoromethyl)phenyl]quinoline.
CATO supplies 7-Methoxy-2-(pyrrolidin-1-yl)-3-[3-(trifluoromethyl)phenyl]quinoline (CAS 1252003-94-3), a certified reference material (molecular formula C21H19F3N2O, MW 372.38 g/mol) for analytical method development and quality control.
The molecular framework of 7-Methoxy-2-(pyrrolidin-1-yl)-3-[3-(trifluoromethyl)phenyl]quinoline (C21H19F3N2O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 7-Methoxy-2-(pyrrolidin-1-yl)-3-[3-(trifluoromethyl)phenyl]quinoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H19F3N2O |
| Molecular Weight | 372.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- (R)-2-Acetamido-3-((2-amino-4-(5-nitrofuran-2-yl)thiazol-5-yl)thio)propanoic acid (CAS 113790-27-5)
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- N-Acetyl-Leucyl-Phenylalanyl Trifluoromethyl Ketone (CAS 113215-69-3)
- (2R,3R,4S,5R)-2-(2-Amino-6-(benzylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (CAS 26783-32-4)
- 6-(4-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid (CAS 1103500-20-4)
- Decarine (CAS 54354-62-0)
- 2-Naphthimidamide hydrochloride (CAS 14948-94-8)
- 6-Methylpyrimidine-2,4(1H,3H)-dithione (CAS 6308-38-9)
- Cefazolin Impurity 36 (CAS 5456-21-3)
- 3,3,4,4-Tetraethoxybut-1-yne (CAS 851900-14-6)
- Drospirenone EP Impurity A (CAS 67372-68-3)
- ((4-Acetamidophenyl)sulfonyl)-L-tryptophan (CAS 85979-07-3)
- 2-((4-Chlorophenyl)thio)-N-(5-(isoxazol-5-yl)-1,3,4-oxadiazol-2-yl)acetamide (CAS 952822-33-2)
- Semaglutide impurity 204 (CAS CATO-C4X-2226204)
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