Drospirenone EP Impurity A CAS 67372-68-3
| CAS No. | 67372-68-3 |
| Molecular Formula | C23H30O3 |
| Molecular Weight | 354.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Drospirenone EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Drospirenone EP Impurity A (CAS 67372-68-3, C23H30O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Drospirenone EP Impurity A (C23H30O3) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C23H30O3 |
| Molecular Weight | 354.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
Related Drospirenone Standards
- Drospirenone Ether Impurity (CAS 90376-21-9)
- Drospirenone EP Impurity D (CAS 67372-69-4)
- Drospirenone Impurity 14 (CAS CATO-C4X-162414)
- Drospirenone (CAS 67392-87-4)
- Drospirenone EP Impurity E (CAS 90457-65-1)
- Drospirenone EP Impurity K (CAS 889652-31-7)
- Drospirenone EP Impurity F (CAS CATO-C4X-16245)
- Drospirenone EP Impurity I (CAS 2896199-04-3)
Recommended Standards
- Mifepristone Impurity 14 (CAS 84371-69-7)
- Prostaglandin E1 (CAS 745-65-3)
- 15-Keto Prostaglandin E0 (Mixture of Tautomeric Isomers) (CAS CATO-C4X-113639)
- Prostaglandin F2a (CAS 551-11-1)
- Palbociclib Impurity 109 (CAS 1974279-20-3)
- Olopatadine Impurity 38 (CAS CATO-C4X-171838)
- Triamcinolone Acetonide EP Impurity B (CAS 1260149-96-9)
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- 2-Chloro-N-(2,6-dimethylphenyl)-N-(furan-2-ylmethyl)acetamide (CAS 53656-13-6)
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- Methyl 5-Methyl-1-p-tolyl-1H-pyrazole-3-carboxylate (CAS 1282440-66-7)
- Palmitoyl Tripeptide-1 TFA salt (CAS 2803375-47-3)
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