Rivaroxaban Impurity N3 CAS 1252018-10-2
| CAS No. | 1252018-10-2 |
| Molecular Formula | C13H17ClN2O3 |
| Molecular Weight | 284.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Rivaroxaban Impurity N3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Rivaroxaban Impurity N3 (CAS 1252018-10-2), a pharmacopoeial impurity reference standard (molecular formula C13H17ClN2O3, MW 284.74 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Rivaroxaban Impurity N3 (C13H17ClN2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H17ClN2O3 |
| Molecular Weight | 284.74 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity N4 (CAS 1252018-21-5)
- Rivaroxaban Impurity 148 (CAS 1450877-56-1)
- Rivaroxaban Open Ring Methylamine (CAS 2459303-14-9)
- Rivaroxaban Impurity 128 (CAS 1265682-11-8)
- Rivaroxaban Impurity 144 (CAS CATO-C4X-1090144)
- Rivaroxaban impurity 197 (CAS CATO-C4X-1090197)
- Rivaroxaban Impurity 4 (CAS 446292-10-0)
- Rivaroxaban Impurity 46 (CAS 1411775-06-8)
Recommended Standards
- 3-(4-Chlorophenyl)-5-(3-methoxyphenyl)-1H-pyrazole (CAS 1204141-87-6)
- 1-(4-Chlorophenyl)-3-p-tolyl-1H-pyrazol-4-ol (CAS 1202029-14-8)
- 2-(Chloromethyl)-N-(pyridin-3-ylmethyl)quinazolin-4-amine (CAS 1255147-54-6)
- 8-Chloro-5-methoxy-2-phenylquinolin-4-amine (CAS 1189107-08-1)
- Fingolimod impurity 26 (CAS 268557-49-9)
- Pazufloxacin Impurity 19 (CAS CATO-C4X-233219)
- Mitiglinide Impurity 27 (CAS CATO-C4X-116127)
- 2-(6-Carbamoylpyridin-3-yl)acetic acid (CAS 2091244-29-8)
- N-(3-(1,1-Dioxidoisothiazolidin-2-yl)phenyl)cyclohexanecarboxamide (CAS 941932-45-2)
- Cetilistat Impurity 8 (CAS 62072-62-2)
- 3,3-difluoro-1-hydroxy-cyclobutanecarboxylic acid (CAS 2297599-09-6)
- 2-(4-Oxo-3-phenyl-4H-chromen-8-yl)acetic acid (CAS 87627-17-6)
- 2-Amino-4-phenylquinoline-3-carbonitrile (CAS 31407-26-8)
- Cyclolinopeptide B (CAS 193139-41-2)
Why CATO?
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