Rivaroxaban Impurity 157 CAS 1252018-07-7
| CAS No. | 1252018-07-7 |
| Molecular Formula | C12H14N2O4 |
| Molecular Weight | 250.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Rivaroxaban Impurity 157 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Rivaroxaban Impurity 157 (CAS 1252018-07-7) is a certified pharmaceutical impurity reference standard with the molecular formula C12H14N2O4 and a molecular weight of 250.25 g/mol.
Structurally, Rivaroxaban Impurity 157 (C12H14N2O4) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 250.25 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H14N2O4 |
| Molecular Weight | 250.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 2 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 120 (CAS CATO-C4X-1090120)
- Rivaroxaban Impurity N6 (CAS 5466-93-3)
- Rivaroxaban Impurity 85 (CAS 1218777-30-0)
- Rivaroxaban Impurity 199 (CAS CATO-C4X-1090199)
- Rivaroxaban Impurity 118 (CAS CATO-C4X-1090118)
- Rivaroxaban Impurity 212 (CAS CATO-C4X-1090212)
- Rivaroxaban Impurity 71 (CAS 811450-82-5)
- Rivaroxaban Impurity 143 (CAS CATO-C4X-1090143)
Recommended Standards
- Apixaban Impurity 31 (CAS CATO-C4X-108831)
- Terbutaline impurity 123 (CAS CATO-C4X-1183123)
- Apixaban impurity 159 (CAS CATO-C4X-1088159)
- Nifedipine Impurity 22 (CAS CATO-C4X-141022)
- Upadacitinib Impurity 216 (CAS CATO-C4X-2405216)
- Melatonin impurity 19 (CAS 1215711-91-3)
- Octreotide EP Impurity E (CAS 1546983-27-0(Free base))
- 1-(4-Chlorobenzyl)piperidin-4-ol (CAS 21937-62-2)
- 2-(4-(Difluoromethyl)-5-fluoro-3-hydroxypyridin-2-yl)acetic acid (CAS 1805582-26-6)
- 4-Bromo-N,N-dimethylcyclohexanamine hydrobromide (CAS 1624260-78-1)
- 4,6-Bis(4-chloro-3-(trifluoromethyl)phenoxy)pyrimidin-2(1H)-one (CAS 329701-38-4)
- 2-Fluoro-3-methoxy-4-(trifluoromethyl)pyridine (CAS 1227574-05-1)
- (6-Chlorobenzo[d]thiazol-2-yl)methanol (CAS 205181-88-0)
- Heme iron polypeptide(Hematin) (CAS 14875-96-8)
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