Decitabine Impurity 1 CAS 1254186-96-3
| CAS No. | 1254186-96-3 |
| Molecular Formula | C12H16N4O6 |
| Molecular Weight | 312.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Decitabine Impurity 1 (CAS 1254186-96-3, C12H16N4O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Decitabine Impurity 1 (C12H16N4O6) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Decitabine Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H16N4O6 |
| Molecular Weight | 312.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 4 |
Related Decitabine Standards
- Decitabine Impurity 4 (CAS CATO-C4X-11374)
- Decitabine Impurity 7 (CAS CATO-C4X-11377)
- Decitabine Impurity 11 (CAS CATO-C4X-113711)
- Decitabine Impurity 2 (CAS CATO-C4X-11372)
- Decitabine Impurity 3 (CAS CATO-C4X-11373)
- Decitabine Impurity 34 (CAS CATO-C4X-113734)
- Decitabine Impurity 5 (CAS CATO-C4X-11375)
- Decitabine Impurity 6 (CAS CATO-C4X-11376)
Recommended Standards
- Capecitabine Impurity 37 (CAS CATO-C4X-102437)
- Bosentan Impurity N8 (CAS 329923-15-1)
- Thalidomide-propargyl (CAS 2098487-39-7)
- Folic Acid EP Impurity D (CAS 119-24-4)
- Goserelin EP Impurity E Acetate (CAS CATO-C4X-192028)
- Sildenafil EP Impurity F (CAS 139755-82-1)
- Avatrombopag Impurity 10 (CAS CATO-C4X-223410)
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- 1-(5-Chloro-4-fluoropyridin-3-yl)ethan-1-one (CAS 1393574-44-1)
- 2-Amino-2-(3-hydroxy-4-methoxyphenyl)acetic acid (CAS 368858-99-5)
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- 1-Benzyl 2-methyl (5R)-5-methyl-3-oxopyrrolidine-1,2-dicarboxylate (CAS 2470016-14-7)
- Acetyl-Tau Peptide (273-284) amide trifluoroacetate salt (CAS 1684399-52-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com