2-Chloro-5-nitro-3-pyridinylethanone CAS 1256264-86-4
| CAS No. | 1256264-86-4 |
| Molecular Formula | C7H5ClN2O3 |
| Molecular Weight | 200.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-5-nitro-3-pyridinylethanone (CAS 1256264-86-4), molecular formula C7H5ClN2O3 and molecular weight 200.58 g/mol, is a CATO reference standard with documented purity and traceability.
2-Chloro-5-nitro-3-pyridinylethanone (C7H5ClN2O3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-5-nitro-3-pyridinylethanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5ClN2O3 |
| Molecular Weight | 200.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
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- 1-(5-Chloro-3-nitropyridin-2-yl)ethanone (CAS 1071691-19-4)
- 2-Chloro-6-nitrobenzamide (CAS 107485-64-3)
- 5-Chloro-3-formyl-2-hydroxybenzoic acid (CAS 111870-27-0)
- 2-Chloro-3-nitrobenzamide (CAS 117054-76-9)
- 1-(2-Chloro-5-nitropyridin-4-yl)ethanone (CAS 1214241-91-4)
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Recommended Standards
- 5-Carbamoyl-3-chloropyridine-2-carboxylic acid (CAS 1200497-79-5)
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- 2-Chloroisophthalic acid (CAS 13049-16-6)
- 5-Carbamoyl-6-chloropyridine-2-carboxylic acid (CAS 1312772-66-9)
- 1h-indole-3-carboxylic acid,4-methoxy 203937-50-2 4-Methoxy-1H-indole-3-carboxylic acid 4-methoxyindole-3-carboxylic acid (CAS 203937-50-2)
- Benzene-1,2,3-triamine dihydrochloride (CAS 66046-54-6)
- 3-[(pyrrolidin-3-yl)amino]benzonitrile hydrochloride (CAS 1955531-78-8)
- 6-Bromo-4-hydrazinyl-2-methylquinoline (CAS 951625-89-1)
- 4-(tert-Butoxy)-5-cyclopropoxy-N,N-dimethylpyridin-2-amine (CAS 1243468-45-2)
- 2-(4-Methyl-3-nitrophenyl)imidazo[1,2-a]pyrimidine-3-carbaldehyde (CAS 1216087-78-3)
- 5-(4-Fluorobenzyl)-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine (CAS 1077629-23-2)
- Arecaidine hydrobromide (CAS 6013-57-6)
- 4-Bromo-4-methylstilbene (CAS 62856-31-9)
- Insulin B (22-25) (CAS 34367-73-2)
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