4-Chloro-2-fluoro-3-isopropoxyphenylboronic acid CAS 1256346-21-0
| CAS No. | 1256346-21-0 |
| Molecular Formula | C9H11BClFO3 |
| Molecular Weight | 232.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chloro-2-fluoro-3-isopropoxyphenylboronic acid (C9H11BClFO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
4-Chloro-2-fluoro-3-isopropoxyphenylboronic acid (CAS 1256346-21-0), molecular formula C9H11BClFO3 and molecular weight 232.44 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H11BClFO3 |
| Molecular Weight | 232.44 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 4-Chloro-2-fluoro-3-propoxyphenylboronic acid (CAS 1256346-23-2)
- (3-Chloro-4-(3-fluoropropoxy)phenyl)boronic acid (CAS 1704080-24-9)
- 3-Chloro-4-fluoro-5-isopropoxyphenylboronic acid (CAS 2096331-77-8)
- 3-Chloro-4-fluoro-5-propoxyphenylboronic acid (CAS 2096331-01-8)
- 3-Chloro-5-fluoro-4-isopropoxyphenylboronic acid (CAS 2096335-18-9)
- 3-Chloro-5-fluoro-4-propoxyphenylboronic acid (CAS 2096341-48-7)
- 5-Chloro-2-fluoro-3-isopropoxyphenylboronic acid (CAS 2096339-37-4)
- 5-Chloro-2-fluoro-4-isopropoxyphenylboronic acid (CAS 2121511-67-7)
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