2-Fluoro-3-(hydroxymethyl)phenylboronic Acid CAS 1256355-08-4
| CAS No. | 1256355-08-4 |
| Molecular Formula | C7H8BFO3 |
| Molecular Weight | 169.95 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Fluoro-3-(hydroxymethyl)phenylboronic Acid.
2-Fluoro-3-(hydroxymethyl)phenylboronic Acid (CAS 1256355-08-4), molecular formula C7H8BFO3 and molecular weight 169.95 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Fluoro-3-(hydroxymethyl)phenylboronic Acid (C7H8BFO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Fluoro-3-(hydroxymethyl)phenylboronic Acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H8BFO3 |
| Molecular Weight | 169.95 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Fluoro Standards
- 2-Fluoro-5-(hydroxymethyl)phenylboronic Acid (CAS 1072952-25-0)
- 3-Fluoro-4-(hydroxymethyl)phenylboronic Acid (CAS 1082066-52-1)
- 3-Fluoro-5-(hydroxymethyl)phenylboronic Acid (CAS 1146614-40-5)
- 5-Fluoro-2-(hydroxymethyl)phenylboronic Acid (CAS 1246633-53-3)
- (2-Fluoro-6-(hydroxymethyl)phenyl)boronic acid (CAS 1246633-54-4)
- (3-Fluoro-2-(hydroxymethyl)phenyl)boronic acid (CAS 1246633-55-5)
- (2-Fluoro-4-(hydroxymethyl)phenyl)boronic acid (CAS 1331945-14-2)
- 2,4,6-Tris(3-fluoro-4-methoxyphenyl)-1,3,5,2,4,6-trioxatriborinane (CAS 149506-26-3)
Recommended Standards
- 3-Fluoro-4-methoxybenzeneboronic acid, 97% (CAS 149507-26-6)
- 2-Fluoro-4-methoxyphenylboronic acid (CAS 162101-31-7)
- 5-Fluoro-2-methoxybenzeneboronic acid, 97% (CAS 179897-94-0)
- 2-Fluoro-6-hydroxy-4-methylphenylboronic acid (CAS 1803598-06-2)
- 2-Chloro-4-(difluoromethyl)-5-methoxy-3-methylpyridine (CAS 1805354-27-1)
- 4-(3,4-Dihydro-2H-benzo[b][1,4]dioxepin-7-yl)benzohydrazide (CAS 952183-14-1)
- 4-(Benzyloxy)-1-(4-fluorophenyl)-N-(2-morpholinoethyl)-1H-pyrazole-3-carboxamide (CAS 1172729-10-0)
- Proparacaine Impurity 13 (CAS CATO-C4X-202713)
- (R)-Benzyl 2-amino-3-(tert-butoxy)propanoate hydrochloride (CAS 1998701-25-9)
- 5-tert-butylimidazolidine-2,4-dione (CAS 169961-91-5)
- 1-(4'-Hydroxy-[1,1'-biphenyl]-3-yl)ethanone (CAS 191724-09-1)
- 1-acetyl-1H-indole-6-carbonitrile (CAS 1017791-09-1)
- 4,6-Diethyl-4,8-dimethyl-4H-pyrrolo-[3,2,1-ij]quinoline-1,2-dione (CAS 774561-60-3)
- D-Lys20-Tirzepatide (CAS CATO-CPTD788914)
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