2-(2,6-Dichlorophenylmethoxy)phenylboronic acid CAS 1256355-85-7
| CAS No. | 1256355-85-7 |
| Molecular Formula | C13H11BCl2O3 |
| Molecular Weight | 296.94 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(2,6-Dichlorophenylmethoxy)phenylboronic acid.
2-(2,6-Dichlorophenylmethoxy)phenylboronic acid (CAS 1256355-85-7) is a high-purity analytical reference standard with the molecular formula C13H11BCl2O3 and a molecular weight of 296.94 g/mol.
The molecular framework of 2-(2,6-Dichlorophenylmethoxy)phenylboronic acid (C13H11BCl2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H11BCl2O3 |
| Molecular Weight | 296.94 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
Related Dichlorophenylmethoxy Standards
Recommended Standards
- (2-((3,4-Dichlorobenzyl)oxy)phenyl)boronic acid (CAS 1256355-84-6)
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- (3-((3,4-Dichlorobenzyl)oxy)phenyl)boronic acid (CAS 1256358-47-0)
- (3-((2,4-Dichlorobenzyl)oxy)phenyl)boronic acid (CAS 1256355-73-3)
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