(4-((2-Chloro-4-fluorobenzyl)oxy)phenyl)boronic acid CAS 1256355-86-8
| CAS No. | 1256355-86-8 |
| Molecular Formula | C13H11BClFO3 |
| Molecular Weight | 280.49 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(4-((2-Chloro-4-fluorobenzyl)oxy)phenyl)boronic acid (CAS 1256355-86-8), molecular formula C13H11BClFO3 and molecular weight 280.49 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (4-((2-Chloro-4-fluorobenzyl)oxy)phenyl)boronic acid (C13H11BClFO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H11BClFO3 |
| Molecular Weight | 280.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-(2-Chloro-5-iodophenyl)ethan-1-one (CAS 100479-73-0)
- (3-((2-Chloro-4-fluorobenzyl)oxy)phenyl)boronic acid (CAS 1256358-45-8)
- {2-[(2-chloro-4-fluorophenyl)methoxy]phenyl}boranediol (CAS 1311184-95-8)
- 1-(3-Chloro-5-iodophenyl)ethan-1-one (CAS 1393541-65-5)
- 1-(3-Chloro-4-iodophenyl)ethan-1-one (CAS 149936-78-7)
- 1-(5-Chloro-2-iodophenyl)ethan-1-one (CAS 1685280-86-7)
- 1-(3-Chloro-2-iodophenyl)ethanone (CAS 1802599-75-2)
- (3-Chloro-4-((2-fluorobenzyl)oxy)phenyl)boronic acid (CAS 870777-28-9)
Recommended Standards
- (2-((3-Chlorobenzyl)oxy)-5-fluorophenyl)boronic acid (CAS 1256355-83-5)
- 2-(2-Chlorophenylmethoxy)-5-fluorophenylboronic acid (CAS 1256355-80-2)
- (2-((4-Chlorobenzyl)oxy)-5-fluorophenyl)boronic acid (CAS 1256358-54-9)
- 3-Benzyloxy-4-chloro-2-fluorophenylboronic acid (CAS 1256346-27-6)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-(3-fluorophenyl)thiophen-2-yl)boronate (CAS 1402174-30-4)
- 2-Hydrazinyl-4-(pyridin-3-yl)pyrimidine (CAS 959037-50-4)
- 2-[4-(3-Methoxyphenyl)-1-piperazinyl]aniline (CAS 937607-69-7)
- Mirabegron impurity 101 (CAS CATO-C4X-1032101)
- n-(4-Iodophenyl)tetrahydrofuran-2-carboxamide (CAS 438455-85-7)
- 1-(2-Bromophenyl)-2-(isobutylthio)ethan-1-one (CAS 1154282-03-7)
- 3-{2-[(3-Bromo[1,1-biphenyl]-4-yl)oxy]-ethyl}piperidine hydrochloride (CAS 1220029-12-8)
- 1-(4-Bromo-2-ethoxyphenyl)ethylamine (CAS 1555255-86-1)
- 1-Bromo-3,5-bis[(1,1-dimethylethyl)thio]benzene (CAS 795274-44-1)
- Semaglutide impurity 101 (CAS CATO-C4X-2226101)
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