6-(3-Fluorophenyl)-2-methylpyrimidine-4-carbonitrile CAS 1256638-63-7
| CAS No. | 1256638-63-7 |
| Molecular Formula | C12H8FN3 |
| Molecular Weight | 213.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-(3-Fluorophenyl)-2-methylpyrimidine-4-carbonitrile (CAS 1256638-63-7) is a high-purity analytical reference standard with the molecular formula C12H8FN3 and a molecular weight of 213.21 g/mol.
The molecular framework of 6-(3-Fluorophenyl)-2-methylpyrimidine-4-carbonitrile (C12H8FN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8FN3 |
| Molecular Weight | 213.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Fluorophenyl Standards
- 6-(4-Fluorophenyl)pyrazolo[1,5-a]pyrimidine (CAS 1036762-04-5)
- 6-(4-Fluorophenyl)-2-methylpyrimidine-4-carbonitrile (CAS 1256638-70-6)
- 2-((3-Fluorophenyl)amino)isonicotinonitrile (CAS 137225-10-6)
- 2-[(4-fluorophenyl)amino]pyridine-4-carbonitrile (CAS 137225-11-7)
- o-(3-Fluorophenyl)homoserine (CAS 1501948-40-8)
- 2-((4-Fluorophenyl)amino)nicotinonitrile (CAS 874754-07-1)
- 2-(2-Fluorophenyl)-3H-Imidazo[4,5-c]pyridine (CAS 89075-43-4)
- 2-(3-Fluorophenyl)-1,3-benzoxazole (CAS 20000-61-7)
Recommended Standards
- 2-Amino-3-(3-fluoro-2-methoxyphenyl)propanoic acid (CAS 1256482-65-1)
- Ethyl 2-amino-5-fluoro-3-methoxybenzoate (CAS 1248661-13-3)
- 4-(3-Cyano-2-fluorophenyl)phenol (CAS 1261951-45-4)
- Methyl 2-amino-5-ethoxy-4-fluorobenzoate (CAS 1248353-15-2)
- Repaglinide acyl-β-D-glucuronide (CAS 1309112-13-7)
- Tert-butyl 7,7-dimethyl-6-oxooctahydro-2H-pyrrolo[3,4-c]pyridine-2-carboxylate (CAS 2387109-50-2)
- 2-(Difluoromethyl)-4-hydroxy-3-(trifluoromethoxy)pyridine-6-carboxylic acid (CAS 1803960-46-4)
- 2-Chloro-N1,N1,N3,N3-tetraphenylbenzene-1,3-diamine (CAS 1800321-78-1)
- Methyl 2-Methyloxazole-5-acetate (CAS 1276083-60-3)
- n-((1-(Dimethylamino)cyclopentyl)methyl)pivalamide (CAS 1197581-06-8)
- (R)-1-(3,5-Dimethoxyphenyl)ethan-1-amine (CAS 1241676-71-0)
- N-Methyl-2-(pyridin-4-yl)pyrimidin-4-amine (CAS 81664-77-9)
- Methyl 5-amino-4-carbamoyl-3-methylthiophene-2-carboxylate (CAS 438611-43-9)
- Semaglutide impurity 44 (CAS CATO-C4X-222644)
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