2-(Difluoromethyl)-4-hydroxy-3-(trifluoromethoxy)pyridine-6-carboxylic acid CAS 1803960-46-4
| CAS No. | 1803960-46-4 |
| Molecular Formula | C8H4F5NO4 |
| Molecular Weight | 273.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Difluoromethyl)-4-hydroxy-3-(trifluoromethoxy)pyridine-6-carboxylic acid (CAS 1803960-46-4), molecular formula C8H4F5NO4 and molecular weight 273.11 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C8H4F5NO4, 2-(Difluoromethyl)-4-hydroxy-3-(trifluoromethoxy)pyridine-6-carboxylic acid contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 273.11 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4F5NO4 |
| Molecular Weight | 273.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 2-(Difluoromethyl)-5-hydroxy-4-(trifluoromethoxy)pyridine-3-carboxylic acid (CAS 1803960-52-2)
- 4-(Difluoromethyl)-6-hydroxy-5-(trifluoromethoxy)picolinic acid (CAS 1803961-10-5)
- 4-(Difluoromethyl)-5-hydroxy-3-(trifluoromethoxy)picolinic acid (CAS 1803961-18-3)
- 2-(Difluoromethyl)-6-hydroxy-3-(trifluoromethoxy)pyridine-5-carboxylic acid (CAS 1804797-53-2)
- 4-(Difluoromethyl)-6-hydroxy-5-(trifluoromethoxy)nicotinic acid (CAS 1804835-37-7)
- 2-(Difluoromethyl)-3-hydroxy-6-(trifluoromethoxy)pyridine-5-carboxylic acid (CAS 1804836-96-1)
- 2-(Difluoromethyl)-5-hydroxy-3-(trifluoromethoxy)pyridine-6-carboxylic acid (CAS 1804837-03-3)
- 2-(Difluoromethyl)-4-hydroxy-5-(trifluoromethoxy)pyridine-3-carboxylic acid (CAS 1804839-87-9)
Recommended Standards
- 1-Difluoromethoxy-2-nitro-3-(trifluoromethoxy)benzene (CAS 1803825-59-3)
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- 3-Chloro-4-ethoxy-5-fluorobenzenesulfonyl chloride (CAS 1706430-92-3)
- 6-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline (CAS 1627721-92-9)
- 3-(2-Oxo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[cd]indol-1(2H)-yl)piperidine-2,6-dione (CAS 2912304-32-4)
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