5-Hydroxy-6-(trifluoromethyl)picolinic acid CAS 1256809-93-4
| CAS No. | 1256809-93-4 |
| Molecular Formula | C7H4F3NO3 |
| Molecular Weight | 207.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Hydroxy-6-(trifluoromethyl)picolinic acid.
5-Hydroxy-6-(trifluoromethyl)picolinic acid (CAS 1256809-93-4), molecular formula C7H4F3NO3 and molecular weight 207.11 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Hydroxy-6-(trifluoromethyl)picolinic acid (C7H4F3NO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Hydroxy-6-(trifluoromethyl)picolinic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4F3NO3 |
| Molecular Weight | 207.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Hydroxy Standards
- 4-Hydroxy-6-(trifluoromethyl)nicotinic acid (CAS 1060810-79-8)
- 4-hydroxy-5-(trifluoromethyl)pyridine-3-carboxylic acid (CAS 1211530-53-8)
- 3-Hydroxy-6-(trifluoromethyl)picolinic acid (CAS 1214362-36-3)
- 2-Hydroxy-3-(trifluoromethyl)isonicotinic acid (CAS 1227514-41-1)
- 2-Hydroxy-5-(trifluoromethyl)isonicotinic acid (CAS 1227594-58-2)
- 4-Hydroxy-6-(trifluoromethyl)picolinic acid (CAS 1256789-28-2)
- 3-Hydroxy-2-(trifluoromethyl)isonicotinic acid (CAS 135245-01-1)
- 3-Hydroxy-5-(trifluoromethyl)picolinic acid (CAS 1806579-86-1)
Recommended Standards
- 6-Amino-2-(trifluoromethyl)pyrimidine-4-carboxylic acid (CAS 1269292-72-9)
- 1-(bromomethyl)-1-ethoxycyclopentane (CAS 1249422-25-0)
- 1-Boc-5-fluoro-1H-indole (CAS 129822-47-5)
- 1-Bromo-2-isopropoxycyclopentane (CAS 1249261-73-1)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(phenyl)methanone (CAS 898761-26-7)
- 3-Phenyl-1H-pyrrolo[2,3-b]pyridine (CAS 10299-55-5)
- 1-Ethyl-3-(3-methoxyphenyl)piperazine (CAS 1248907-87-0)
- Sodium 5-Amino-2-hydroxybenzoate (CAS 35589-28-7)
- Methyl 3-(2-(4-formylphenoxy)ethoxy)benzoate (CAS 937601-95-1)
- Thioctic acid Impurity 76 (CAS CATO-C4X-152676)
- Peptide Impurity 24 (CAS CATO-CPTD788824)
- Rivastigmine Impurity 20 (CAS CATO-C4X-138420)
- 5-Bromo-3-(piperidine-1-carbonyl)phenylboronic acid (CAS 2121514-06-3)
- 551936-17-5 3JX85UOO24 AIM-102 UNII-3JX85UOO24 (4R)-4-(((2R)-2-Amino-3-cyclohexyl-propanoyl)amino)-5-(carboxymethylamino)-5-oxo-pentanoic acid D-Cyclohexylalanine-D-glutamic-glycine tripeptide Glycine, 3-cyclohexyl-D-alanyl-D-alpha-glutamyl- (CAS 551936-17-5)
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