1-(5-Chloro-3-hydroxypyridin-2-yl)ethanone CAS 1256811-58-1
| CAS No. | 1256811-58-1 |
| Molecular Formula | C7H6ClNO2 |
| Molecular Weight | 171.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(5-Chloro-3-hydroxypyridin-2-yl)ethanone.
1-(5-Chloro-3-hydroxypyridin-2-yl)ethanone (CAS 1256811-58-1), molecular formula C7H6ClNO2 and molecular weight 171.58 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 1-(5-Chloro-3-hydroxypyridin-2-yl)ethanone (C7H6ClNO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 171.58 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(5-Chloro-3-hydroxypyridin-2-yl)ethanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6ClNO2 |
| Molecular Weight | 171.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 3-chloro-4-hydroxybenzamide (CAS 1007578-86-0)
- 4-Chloro-2-methoxynicotinaldehyde (CAS 1008451-58-8)
- 6-Chloro-N'-hydroxypicolinimidamide (CAS 1042151-12-1)
- 2-Chloro-4-hydroxybenzamide (CAS 1046818-83-0)
- 2-Chloro-6-hydroxybenzamide (CAS 1056958-24-7)
- 4-Chloro-5-methoxypyridine-2-carbaldehyde (CAS 1060801-63-9)
- 2-Chloro-5-methoxyisonicotinaldehyde (CAS 1060801-65-1)
- 6-Chloro-5-methoxynicotinaldehyde (CAS 1060801-67-3)
Recommended Standards
- 5-Chloro-4-methoxypicolinaldehyde (CAS 1256790-77-8)
- 1-(2-Chloro-3-hydroxypyridin-4-yl)ethanone (CAS 1256818-94-6)
- 4-Chloro-5-methoxynicotinaldehyde (CAS 1256789-11-3)
- 1-(3-Chloro-5-hydroxypyridin-2-yl)ethanone (CAS 1256819-84-7)
- 6-Chloro-1-methyl-1,2,3,4-tetrahydroquinolin-4-amine (CAS 1243449-92-4)
- 2,2,3,3,3-Pentafluoro-1-(4-methoxy-3,5-dimethylphenyl)propan-1-one (CAS 1443314-51-9)
- (E)-Doxepin (CAS 3607-34-9)
- 2-(2-Bromothiazol-5-yl)ethanamine (CAS 910401-29-5)
- 2-Bromoacetamide (CAS 683-57-8)
- 1-(2-Ethoxyethyl)cyclobutane-1-carboxylic acid (CAS 1421601-21-9)
- N-Phenyl 4-bromonaphthamide (CAS 87700-83-2)
- S)-tert-Butyl (2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate (CAS 1448440-50-3)
- (+)-(3R,4S)-3-fluoro-1-methylsulfonyl-piperidin-4-amine (CAS 2186605-05-8)
- DAPK Substrate Peptide (CAS 386769-53-5)
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