5-(Chloromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one CAS 1258651-02-3
| CAS No. | 1258651-02-3 |
| Molecular Formula | C7H6ClN3O |
| Molecular Weight | 183.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-(Chloromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one (CAS 1258651-02-3), molecular formula C7H6ClN3O and molecular weight 183.60 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, 5-(Chloromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 183.60 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6ClN3O |
| Molecular Weight | 183.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloromethyl Standards
- 2-(Chloromethyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (CAS 1622233-20-8)
- 2-(Chloromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one (CAS 58333-27-0)
- 2-(Chloromethyl)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole (CAS 76059-23-9)
- 8-(Chloromethyl)-1H-purin-6-amine (CAS 317337-02-3)
- 2-(chloromethyl)-1,3-benzoxazol-6-ol (CAS 136535-21-2)
- 6-(Chloromethyl)pyridine-2,4-dicarbaldehyde (CAS 1393550-18-9)
- 4-(chloromethyl)-5-(furan-2-yl)-1,2-oxazole (CAS 1423033-19-5)
- 2-(Chloromethyl)-5-hydroxybenzo[d]oxazole (CAS 1803809-69-9)
Recommended Standards
- 4-Chloro-5-methyl-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one (CAS 1226804-06-3)
- 2-Chloro-4-hydrazinyl-5H-pyrrolo[2,3-d]pyrimidine (CAS 1260667-61-5)
- 2-Chloro-8-methoxy-[1,2,4]triazolo[1,5-a]pyridine (CAS 1207970-17-9)
- 2-Chloro-5-methoxy-3H-imidazo[4,5-b]pyridine (CAS 1260672-20-5)
- 2-Bromomethyl-1-isopropoxy-4-nitrobenzene (CAS 1154944-02-1)
- 2-(3-Amino-2,6-dichlorophenyl)acetonitrile (CAS 850451-79-5)
- 4-Bromo-6-(difluoromethyl)pyridin-3-ol (CAS 1806763-94-9)
- 5-Bromo-7-fluoro-1-methyl-1H-indazole (CAS 1379366-71-8)
- Ethyl 3-(diphenylphosphino)benzoate (CAS 223511-00-0)
- 6-Chloro-1-methyl-2,3-dihydro-1h-indole-2-thione (CAS 156136-70-8)
- 5,6-Difluoroquinolin-8-amine (CAS 1242094-79-6)
- 3-Amino-1-tosylazepan-4-ol (CAS 1246891-80-4)
- (R)-tert-Butyl (1-cyclobutylpiperidin-3-yl)carbamate (CAS 2730880-33-6)
- Semaglutide impurity 24 (CAS CATO-C4X-222624)
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