Mitapivat Impurity 1 CAS 1260081-87-5
| CAS No. | 1260081-87-5 |
| Molecular Formula | C20H20N4O3S |
| Molecular Weight | 396.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 396.46 g/mol gives Mitapivat Impurity 1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Mitapivat Impurity 1 (CAS 1260081-87-5) is a certified pharmaceutical impurity reference standard with the molecular formula C20H20N4O3S and a molecular weight of 396.46 g/mol.
Mitapivat Impurity 1 (C20H20N4O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Mitapivat Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H20N4O3S |
| Molecular Weight | 396.46 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Mitapivat Standards
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- Methotrexate EP Impurity I (CAS 66147-29-3)
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- 3,3',3''-(((2,4,6-Trimethylbenzene-1,3,5-triyl)tris(methylene))tris(oxy))tribenzoic acid (CAS 1417713-93-9)
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- N-(2,4-dichlorophenyl)-2-((2-((4-methylphenyl)sulfonamido)phenyl)thio)acetamide (CAS 477869-04-8)
- D-Ser12-Semaglutide (CAS CATO-C4X-2226240)
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