3-Methyl-1-(3-(trifluoromethyl)phenyl)-1h-pyrazole-5-carboxylicacid CAS 126067-58-1
| CAS No. | 126067-58-1 |
| Molecular Formula | C12H9F3N2O2 |
| Molecular Weight | 270.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Methyl-1-(3-(trifluoromethyl)phenyl)-1h-pyrazole-5-carboxylicacid.
3-Methyl-1-(3-(trifluoromethyl)phenyl)-1h-pyrazole-5-carboxylicacid (CAS 126067-58-1), molecular formula C12H9F3N2O2 and molecular weight 270.21 g/mol, is a CATO reference standard with documented purity and traceability.
3-Methyl-1-(3-(trifluoromethyl)phenyl)-1h-pyrazole-5-carboxylicacid (C12H9F3N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H9F3N2O2 |
| Molecular Weight | 270.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Methyl Standards
- 3-{[3-(trifluoromethyl)-1h-pyrazol-1-yl]methyl}benzoic acid (CAS 1004643-62-2)
- 4-{[3-(trifluoromethyl)-1h-pyrazol-1-yl]methyl}benzoic acid (CAS 1006482-42-3)
- 1-Benzyl-5-(trifluoromethyl)-1h-pyrazole-4-carboxylic acid (CAS 1152504-29-4)
- 5-Methyl-2-[3-(trifluoromethyl)phenyl]-1H-imidazole-4-carboxylic Acid (CAS 1153734-86-1)
- 5-Methyl-1-(2-(trifluoromethyl)phenyl)-1h-pyrazole-4-carboxylic acid (CAS 1169957-94-1)
- 1-(4-(Trifluoromethyl)benzyl)-1h-pyrazole-4-carboxylic acid (CAS 1174666-17-1)
- 1-(2-(Trifluoromethyl)benzyl)-1h-pyrazole-4-carboxylic acid (CAS 1177346-90-5)
- (3-((4-(Trifluoromethyl)pyrimidin-2-yl)oxy)phenyl)methanol (CAS 1215524-83-6)
Recommended Standards
- (1-(2-((tert-Butyldimethylsilyl)oxy)ethyl)-1H-pyrazol-3-yl)boronic acid (CAS 1257997-25-3)
- 5-Methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylicacid (CAS 126067-60-5)
- 2-(4-(Trifluoromethoxy)phenyl)pyrimidine-5-methanol (CAS 1257426-65-5)
- 4-Methyl-2-(2-(trifluoromethyl)phenyl)-1H-imidazole-5-carboxylic acid (CAS 1260772-25-5)
- 2-Amino-6-ethyl-5-methylpyrimidin-4(1H)-one (CAS 134277-54-6)
- tert-butyl (4S)-4-(tert-butoxycarbonylamino)-3-chloro-2-methyl-spiro[4,6-dihydropyrrolo[1,2-b]pyrazole-5,4'-piperidine]-1'-carboxylate (CAS 2843691-06-3)
- 3-Quinolinecarboxylic Acid, 1,2-dihydro-4-hydroxy-1-(1-methylethyl)-2-oxo-, ethyl ester (CAS 175282-78-7)
- 2-Ethoxy-6-methylbenzonitrile (CAS 90259-38-4)
- 4-(Aminomethyl)-2-(difluoromethyl)-5-methylpyridin-3-ol (CAS 1806973-99-8)
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