2-(4-Bromo-2-fluorophenyl)quinazoline CAS 1260811-76-4

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(4-Bromo-2-fluorophenyl)quinazoline.

2-(4-Bromo-2-fluorophenyl)quinazoline (CAS 1260811-76-4), molecular formula C14H8BrFN2 and molecular weight 303.13 g/mol, is a CATO reference standard with documented purity and traceability.

2-(4-Bromo-2-fluorophenyl)quinazoline (C14H8BrFN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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