Apixaban 4,5-Dehydro Carboxylic Acid CAS 2518444-61-4
| CAS No. | 2518444-61-4 |
| Molecular Formula | C25H22N4O5 |
| Molecular Weight | 458.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Apixaban 4,5-Dehydro Carboxylic Acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Apixaban 4,5-Dehydro Carboxylic Acid (CAS 2518444-61-4, C25H22N4O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Apixaban 4,5-Dehydro Carboxylic Acid (C25H22N4O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 458.47 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C25H22N4O5 |
| Molecular Weight | 458.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Nitrogen Atoms | 4 |
Related Apixaban Standards
Recommended Standards
- Travoprost Impurity 31((±)-Fluprostenol) (CAS 40666-16-8)
- Eltrombopag N-Oxide Impurity (CAS CATO-C4X-11981)
- Travoprost Impurity 19（15(S)-Fluprostenol） (CAS 54276-24-3)
- Eltrombopag Impurity 155 (CAS CATO-C4X-1198155)
- Posaconazole Impurity 42 (CAS CATO-C4X-141842)
- Melphalan Impurity 33 (CAS CATO-C4X-198833)
- Neostigmine impurity 01 (CAS 618-09-7)
- 2-(3,4-Dihydroxybutyl)quinoxaline (CAS 80840-08-0)
- 3-Amino-5-methoxyphenol (CAS 162155-27-3)
- 5-Ethyl-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol (CAS 1031967-54-0)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(2-phenylacetyl)-1H-pyrrole-2-carbonitrile (CAS 338397-77-6)
- 3-Iodopyrazolo[1,5-a]pyrimidin-5(4H)-one (CAS 1224944-44-8)
- 1-(Bromomethyl)-1-(sec-butoxy)-3-methylcyclohexane (CAS 1249446-95-4)
- (9-D-Asp) Semaglutide X Sodium salt (CAS CATO-CPTD788617)
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