3-(4-Methoxy-3-(trifluoromethoxy)phenyl)propanoic acid CAS 1261587-75-0
| CAS No. | 1261587-75-0 |
| Molecular Formula | C11H11F3O4 |
| Molecular Weight | 264.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-(4-Methoxy-3-(trifluoromethoxy)phenyl)propanoic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-(4-Methoxy-3-(trifluoromethoxy)phenyl)propanoic acid (CAS 1261587-75-0), molecular formula C11H11F3O4 and molecular weight 264.20 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 3-(4-Methoxy-3-(trifluoromethoxy)phenyl)propanoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 264.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H11F3O4 |
| Molecular Weight | 264.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Methoxy Standards
- 3-(2-Methoxy-5-(trifluoromethoxy)phenyl)propanoic acid (CAS 1017779-17-7)
- 4-Methoxy-3-[(2,2,2-trifluoroethoxy)methyl]-benzoic acid (CAS 1119449-79-4)
- Ethyl 4-methoxy-2-(trifluoromethoxy)benzoate (CAS 1186195-26-5)
- Ethyl 3-methoxy-4-(trifluoromethoxy)benzoate (CAS 1261582-69-7)
- (2-Methoxy-5-(pentafluoro-lambda6-sulfanyl)phenyl)methanol (CAS 1240257-12-8)
- Ethyl 5-methoxy-7-nitro-1H-indole-2-carboxylate (CAS 13838-44-3)
- Ethyl 7-methoxy-5-nitro-1H-indole-2-carboxylate (CAS 176956-21-1)
- Methyl 2-(2-methoxy-4-(1H-tetrazol-1-yl)phenoxy)acetate (CAS 936081-95-7)
Recommended Standards
- 4-(2-Methoxyethoxy)-3-(trifluoromethyl)benzoic acid (CAS 1271093-46-9)
- 2,2,2-trifluoroethyl N-{5H,6H,7H-pyrrolo[2,1-c][1,2,4]triazol-3-ylmethyl}carbamate (CAS 1241245-03-3)
- 2,2,2-Trifluoro-1-(5-fluoro-2-thioxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)ethanone (CAS 128691-98-5)
- 4-(2-(Trifluoromethoxy)phenyl)picolinonitrile (CAS 1219454-27-9)
- 3-(4-(3-Methoxyphenyl)piperazin-1-yl)propanoic acid (CAS 631090-80-7)
- 2-(4-Aminopiperidin-1-yl)-5-ethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one (CAS 1707399-17-4)
- 3-Cyclopentyl-7-thiomorpholinopyrimido[4,5-d]pyrimidine-2,4(3H,8H)-dione (CAS 1396876-33-7)
- N,N-dimethyl-4-(2-phenylacetyl)-1H-pyrrole-2-carboxamide (CAS 338403-34-2)
- 1-(4-(Trifluoromethyl)benzo[d]oxazol-2-yl)ethanone (CAS 1806528-45-9)
- 2-(1-Aminoethyl)pyrimidin-4-ol (CAS 1342844-43-2)
- 2-(5-Fluoro-2-nitrophenoxy)ethan-1-amine (CAS 1178182-90-5)
- 4-Chloro-N-[2-(2-fluorophenoxy)ethyl]benzamide (CAS 839693-48-0)
- N-(3-(dimethylamino)propyl)-4-(3-methylbutanoyl)-1H-pyrrole-2-carboxamide (CAS 439111-93-0)
- C-Peptide 2 (rat) (CAS 41594-08-5)
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